In this study, a negative Poisson’s ratio honeycomb structure skeleton aimed at enhancing the mechanical properties of artificial blood vessels is proposed. The theoretical mechanical model of the negative Poisson’s ratio honeycomb structure was established, and the key parameters influencing its mechanical properties were identified. The optimal value intervals and design points of the optimized structure were determined using response surface methodology and a multi-objective genetic algorithm combined with finite element simulation software. The accuracy of the multi-objective parameter optimization was analyzed by comparing simulation results from various sample points with the optimal parameter points. Subsequently, the radial resilience of the optimized structure was analyzed. The findings demonstrate that the honeycomb structural skeleton with a negative Poisson’s ratio, designed in this study, exhibits favorable radial resilience.
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