It is very important to establish a life prediction model that evaluates the combined high and low cycle fatigue (CCF) damage of materials. Based on the toughness exhaustion, this paper develops a CCF life prediction model considering loading interaction effect. The loading interaction factor is proposed to reflect the interaction effect between high cycle fatigue and low cycle fatigue. The proposed model does not require any additional material parameters and is convenient for application. The experimental data of four materials including GH4033 Ni-basis alloy, TC11 titanium alloy, LY12-CZ aluminum alloy, and 45 steel are applied to verify the proposed model. Comparing the prediction results of the proposed model with the Miner’s rule and the T-K model, the results show that the predicted results of the proposed model are more satisfactory.
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