Objectives: The study was conducted to examine sex differences in the initial level and rate of change in physical function and grip strength. Method: The baseline survey included 2,262 Danes born in 1905 and alive in 1998 and followed-up in 2000, 2003, and 2005. Hence, the authors fully used the power of having a cohort with multiple assessments in late life and virtually complete follow-up of lifespan (through December 2008). Latent growth curve modeling was used. Results: Men had higher initial levels and rates of decline in strength score and grip strength. Lifespan was positively correlated with intercepts and slopes. Discussion: The Danish data suggested that the longest-living individuals have higher initial levels of strength score and grip strength and smaller rate of change. The data further suggested that the initial level of strength score and grip strength was more predictive of mortality than the rate of change was, and the predictive effects were similar in men and women.
Arber, S., & Cooper, H. ( 1999). Gender differences in health in later life: The new paradox ? Social Science and Medicine, 48(1), 61-76.
2.
Avlund, K., Davidsen, M., & Schultz-Larsen, K. (1995). Changes in functional ability from ages 70 to 75: A Danish longitudinal study. Journal of Aging and Health, 7, 254-282.
3.
Bambra, C., Pope, D.P., Swami, V., Stanistreet, D.L., Roskam, A.-J., Kunst, A.E., et al. (2008). Gender, health inequalities and welfare state regimes: A cross-national study of thirteenEuropean countries. Journal of Epidemiology and Community Health, 63, 38-44.
4.
Barford, A., Dorling, D., Smith, G.D., & Shaw, M. ( 2006). Life expectancy: Women now on top everywhere. British Medical Journal, 332(7545), 808.
5.
Bassey, E.J. ( 1998). Longitudinal changes in selected physical capabilities: Muscle strength, flexibility and body size. Age and Ageing , 27(Suppl. 3), 12-16.
6.
Bassil, N., Alkaade, S., & Morley, J. ( 2009). The benefits and risks of testosterone replacement therapy: A review. Journal of Therapy & Clinical Risk Management , 5, 427-448.
7.
Beckett, L.A., Brock, D.B., Lemke, J.H., de Leon, C.F.M., Guralnik, J.M., Fillenbaum, G.G., et al. (1996). Analysis of change in self-reported physical function among older persons in four population studies. American Journal of Epidemiology, 143, 766-778.
8.
Bosworth, H.B., Schaie, K.W., & Willis, S.L. ( 1999). Cognitive and sociodemographic risk factors for mortality in the Seattle Longitudinal Study. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 54, 273-282.
9.
Bosworth, H.B., & Siegler, I.C. ( 2002). Terminal change in cognitive function: An updated review of longitudinal studies. Experimental Aging Research, 28, 299-315.
10.
Bryk, A.S., & Raudenbush, S.W. (1992). Hierarchical linear models: Applications and data analysis methods (Vol. 16). Thousand Oaks, CA: Sage.
11.
Case, A., & Paxson, C. ( 2005). Sex differences in morbidity and mortality. Demography, 42, 189-214.
12.
Christensen, K., Bathum, L., & Christiansen, L. (2008). Biological indicators and genetic information in Danish twin and oldest-old surveys. In M. Weinstein, J. Vaupel, & K. Wachter (Eds.), Biosocial surveys (pp. 15-41). Washington, DC: National Academy Press.
13.
Christensen, K., Frederiksen, H., Vaupel, J.W., & McGue, M. ( 2003). Age trajectories of genetic variance in physical functioning: A longitudinal study of Danish twins aged 70 years and older. Behavioral Genetics, 33(2), 125-136.
14.
Christensen, K., Gaist, D., Vaupel, J.W., & McGue, M. ( 2002). Genetic contribution to rate of change in functional abilities among Danish twins aged 75 years or more. American Journal of Epidemiology, 155(2), 132-139.
15.
Christensen, K., Holm, N.V., McGue, M., Corder, L., & Vaupel, J.W. ( 1999). A Danish population-based twin study on general health in the elderly. Journal of Aging and Health, 11, 49-64.
16.
Christensen, K., McGue, M., Petersen, I., Jeune, B., & Vaupel, J.W. ( 2008). Exceptional longevity does not result in excessive levels of disability. Proceedings of National Academy of Science , 105, 13274-13279.
17.
Christensen, K., McGue, M., Yashin, A., Iachine, I., Holm, N.V., & Vaupel, J.W. ( 2000). Genetic and environmental influences on functional abilities in Danish twins aged 75 years and older. Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, 55, 446-452.
18.
Deeg, D.J.H., Hofman, A., & van Zonneveld, R.J. (1990). The association between change in cognitive function and longevity in Dutch elderly. American Journal of Epidemiology, 132, 973-982.
19.
Dufouil, C., Brayne, C., & Clayton, D. ( 2004). Analysis of longitudinal studies with death and drop-out: A case study. Statistics in Medicine, 23, 2215-2226.
20.
Forrest, K.Y.Z., Zmuda, J.M., & Cauley, J.A. ( 2005). Patterns and determinants of muscle strength change with aging in older men. Aging Male, 8(3-4), 151-156.
21.
Forrest, K.Y.Z., Zmuda, J.M., & Cauley, J.A. ( 2007). Patterns and correlates of muscle strength loss in older women. Gerontology, 53(3), 140-147.
22.
Frederiksen, H., Hjelmborg, J., Mortensen, J., McGue, M., Vaupel, J.W., & Christensen, K. (2006). Age trajectories of grip strength: Cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102. Annals of Epidemiology, 16, 554-562.
23.
Fujita, Y., Nakamura, Y., Hiraoka, J., Kobayashi, K., Sakata, K., Nagai, M., et al. (1995). Physical-strength tests and mortality among visitors to health-promotion centers in Japan. Journal of Clinical Epidemiology, 48, 1349-1359.
24.
Gale, C.R., Martyn, C.N., Cooper, C., & Sayer, A.A. ( 2007). Grip strength, body composition, and mortality. International Journal of Epidemiology, 36, 228-235.
25.
Ghisletta, P. ( 2008). Application of a joint multivariate longitudinal-survival analysis to examine the terminal decline hypothesis in the Swiss Interdisciplinary Longitudinal Study on the Oldest Old. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 63, 185-192.
26.
Giampaoli, S., Ferrucci, L., Cecchi, F., Lo Noce, C., Poce, A., Dima, F., et al. (1999). Hand-grip strength predicts incident disability in non-disabled older men. Age and Ageing, 28, 283-288.
27.
Human Mortality Database. (2009). Retrieved August 27, 2009, from www.mortality.org
28.
Hughes, V.A., Frontera, W.R., Wood, M., Evans, W.J., Dallal, G.E., Roubenoff, R., et al. (2001). Longitudinal muscle strength changes in older adults: Influence of muscle mass, physical activity, and health. Journals of Gerontology: Series A, Biological Sciences and Medical Sciences , 56, 209-217.
29.
Jeune, B., Skytthe, A., Cournil, A., Greco, V., Gampe, J., Berardelli, M., et al. (2006). Handgrip strength among nonagenarians and centenarians in three European regions. Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, 61, 707-712.
30.
Katz, S., Ford, A.B., Moskowitz, R.W., Jackson, B.A., & Jaffe, M.W. ( 1963). Studies of illness in the aged: The Index of ADL: A standardized measure of biological and psychosocial function. Journal of American Medical Association, 185, 914-919.
31.
Kliegel, M., Moor, C., & Rott, C. ( 2004). Cognitive status and development in the oldest old: A longitudinal analysis from the Heidelberg Centenarian Study. Archives of Gerontology and Geriatrics, 39, 143-156.
32.
Lamberts, S.W.J., van den Beld, A.W., & van der Lely, A.-J. (1997). The endocrinology of aging. Science, 278, 419-424.
33.
Laukka, E.J., MacDonald, S.W.S., & Backman, L. ( 2006). Contrasting cognitive trajectories of impending death and preclinical dementia in the very old. Neurology, 66, 833-838.
34.
Lavery, L.L. , Dodge, H.H., Snitz, B., & Ganguli, M. ( 2009). Cognitive decline and mortality in a community-based cohort: The Monongahela Valley Independent Elders Survey. Journal of the American Geriatrics Society, 57(1), 94-100.
35.
Leveille, S.G., Penninx, B.W., Melzer, D., Izmirlian, G., & Guralnik, J.M. (2000). Sex differences in the prevalence of mobility disability in old age: The dynamics of incidence, recovery, and mortality. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 55, 41-50.
36.
Liang, J., Bennett, J.M., Shaw, B.A., Quinones, A.R., Ye, W., Xu, X., et al. (2008). Gender differences in functional status in middle and older age: Are there any age variations?Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 63, 282-292.
37.
Manton, K.G., Corder, L., & Stallard, E. ( 1993). Changes in the use of personal assistance and special equipment from 1982 to 1989: Results from the 1982 and 1989 NLTCS. Gerontologist, 33, 168-176.
38.
McCullough, M.E., & Laurenceau, J.P. (2004). Gender and the natural history of self-rated health: A 59-year longitudinal study. Health Psychology, 23, 651-655.
39.
Metter, E.J., Talbot, L.A., Schrager, M., & Conwit, R.A. ( 2004). Arm-cranking muscle power and arm isometric muscle strength are independent predictors of all-cause mortality in men. Journal of Applied Physiology, 96, 814-821.
40.
Nathanson, C.A. ( 1975). Illness and the feminine role: A theoretical review. Social Science and Medicine, 9(2), 57-62.
41.
Neale, M., Boker, S., Xie, G., & Maes, H. ( 2003). Mx: Statistical modeling (6th ed.). Richmond, VA: Department of Psychiatry.
42.
Nybo, H., Gaist, D., Jeune, B., Bathum, L., McGue, M., Vaupel, J.W., et al. (2001). The Danish 1905 Cohort: A genetic-epidemiological nationwide survey. Journal of Aging and Health, 13, 32-46.
43.
Nybo, H., Gaist, D., Jeune, B., McGue, M., Vaupel, J.W., & Christensen, K. (2001). Functional status and self-rated health in 2,262 nonagenarians: The Danish 1905 Cohort Survey. Journal of the American Geriatrics Society, 49, 601-609.
44.
Nybo, H., Petersen, H.C., Gaist, D., Jeune, B., Andersen, K., McGue, M., et al. (2003). Predictors of mortality in 2,249 nonagenarians: The Danish 1905-Cohort Survey. Journal of the American Geriatrics Society, 51, 1365-1373.
45.
O’Donnell, A.B., Travison, T.G., Harris, S.S., Tenover, J.L., & McKinlay, J.B. (2006). Testosterone, dehydroepiandrosterone, and physical performance in older men: Results from the Massachusetts Male Aging Study. Journal of Clinical Endocrinology and Metabolism , 91, 425-431.
46.
Olsen, K.M., & Dahl, S.-A. ( 2007). Health differences betweenEuropean countries. Social Science and Medicine, 64, 1665-1678.
47.
Onder, G., Penninx, B.W.J.H., Lapuerta, P., Fried, L.P., Ostir, G.V., Guralnik, J.M., et al. (2002). Change in physical performance over time in older women: The Women’s Health and Aging Study. Journals of Gerontology: Series A, Biological Sciences and Medical Sciences , 57, 289-293.
48.
Oxford, K.L. ( 2000). Elbow positioning for maximum grip performance. Journal of Hand Therapy, 13(1), 33-36.
49.
Pedersen, C.B., Gøtzsche, H., Moller, J.O., & Mortensen, P.B. (2006). The Danish Civil Registration System. A cohort of eight million persons. Danish Medical Bulletin, 53, 441-449.
50.
Proctor, D.N., Fauth, E.B., Hoffman, L., Hofer, S.M., McClearn, G.E., Berg, S., et al. (2006). Longitudinal changes in physical functional performance among the oldest old: Insight from a study of Swedish twins. Aging Clinical & Experimental Research, 18, 517-530.
51.
Rantanen, T., Era, P., & Heikkinen, E. ( 1997). Physical activity and the changes in maximal isometric strength in men and women from the age of 75 to 80 years. Journal of the American Geriatrics Society, 45, 1439-1445.
52.
Rantanen, T., Guralnik, J.M., Foley, D., Masaki, K., Leveille, S., Curb, J.D., et al. (1999). Midlife hand grip strength as a predictor of old age disability. Journal of the American Medical Association , 281, 558-560.
53.
Rantanen, T., & Heikkinen, E. ( 1998). The role of habitual physical activity in preserving muscle strength from age 80 to age 85 years. Journal of Aging and Physical Activity, 6, 121-132.
54.
Rantanen, T., Masaki, K., Foley, D., Izmirlian, G., White, L., & Guralnik, J.M. (1998). Grip strength changes over 27 yr in Japanese-American men. Journal of Applied Physiology , 85, 2047-2053.
55.
Schaap, L.A., Pluijm, S.M.F., Deeg, D.J.H., Penninx, B.W., Nicklas, B.J., Lips, P., et al. (2008). Low testosterone levels and decline in physical performance and muscle strength in older men: Findings from two prospective cohort studies. Clinical Endocrinology, 68(1), 42-50.
56.
Schultz-Larsen, K., Avlund, K., & Kreiner, S. ( 1992). Functional ability of community dwelling elderly. Criterion-related validity of a new measure of functional ability. Journal of Clinical Epidemiology, 45, 1315-1326.
57.
Schupf, N., Tang, M.X., Albert, S.M., Costa, R., Andrews, H., Lee, J.H., et al. (2005). Decline in cognitive and functional skills increases mortality risk in non-demented elderly. Neurology , 65, 1218-1226.
58.
Sehl, M.E., & Yates, F.E. ( 2001). Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people. Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, 56(5), 198-208.
59.
Snowdon, D.A., Greiner, L.H., & Markesbery, W.R. (2000). Linguistic ability in early life and the neuropathology of Alzheimer’s Disease and cerebrovascular disease: Findings from the Nun Study. Annals of the New York Academy of Sciences, 903, 34-38.
60.
Syddall, H., Cooper, C., Martin, F., Briggs, R., & Sayer, A.A. ( 2003). Is grip strength a useful single marker of frailty? Age and Ageing, 32, 650-656.
61.
Taylor, M.G., & Lynch, S.M. ( 2004). Trajectories of impairment, social support, and depressive symptoms in later life. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 59, 238-246.
62.
van den Beld, A.W., de Jong, F.H., Grobbee, D.E., Pols, H.A., & Lamberts, S.W. (2000). Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. Journal of Clinical Endocrinology and Metabolism, 85, 3276-3282.
63.
van Geel, T.A.C.M., Geusens, P.P., Winkens, B., Sels, J.-P.J.E., & Dinant, G.-J. ( 2009). Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: A cross-sectional study. European Journal of Endocrinology, 160, 681-687.
64.
Vianna, L.C., Oliveira, R.B., & Araujo, C.G. ( 2007). Age-related decline in handgrip strength differs according to gender. Journal of Strength & Conditioning Research , 21, 1310-1314.
65.
Waldron, I. ( 1985). What do we know about causes of sex differences in mortality? A review of the literature. Population Bulletin UN, 18, 59-76.
66.
Wilson, R.S., Beck, T.L., Bienias, J.L., & Bennett, D.A. ( 2007). Terminal cognitive decline: Accelerated loss of cognition in the last years of life. Psychosomatic Medicine, 69(2), 131-137.
