Eradication ofHelicobacter pylori in the Treatment of Peptic Ulcer Disease

Abstract

Helicobacter pylori is responsible for the majority of cases of peptic ulcer disease. Peptic ulcer disease should no longer be regarded as a “chronic, recurring, lifelong disease, but rather a curable infection.” Treatment and eradication of H. pylori infection in patients with peptic ulcer disease has been shown to resolve the chronic inflammation present and prevent further ulcer relapse. Despite the vast amount of literature on H. pylori infection in peptic ulcer disease, the diagnosis and management of this common infection have become increasingly straightforward. This article will summarize the role of H. pylori in patients with peptic ulcer disease and will address the current clinical practice guidelines for diagnosis and treatment of H. pylori in the subset of patients.