Metronidazole is a nitroimidazole antibacterial agent that is highly effective for the treatment of protozoal and anaerobic infections. Metronidazole is known to cause hematologic adverse effects, including a reversible mild neutropenia; in rare circumstances, thrombocytopenia has been associated with metronidazole treatment. We present a case of aplastic anemia related to the extended use of metronidazole.
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El-NahasAFel-AshmawyIM. Reproductive and cytogenetic toxicity of metronidazole in male mice. Basic Clin Pharmacol Toxicol. 2004;94(5):226–231.
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MenéndezDRojasEHerreraLA, et al.DNA breakage due to metronidazole treatment. Mutat Res. 2001;478:153–158.
