To study the adsorption of erythropoietin and growth hormone to dialysis bags and tubing.
Design
In vitro study in which radiolabeled erythropoietin and recombinant human growth hormone were added to small-volume (50- and 250-mL) dialysis bags. Recovery was measured after 15-minute dwells. Experiments were performed in triplicate.
Setting
University hospital.
Results
Adsorption of erythropoietin and growth hormone was less than 7%.
Conclusion
Adsorption of erythropoietin and recombinant human growth hormone to dialysis bags and tubing is minimal. This finding provides another argument in favor of intraperitoneal therapy in pediatric peritoneal dialysis.
FineR.N., FineS.E., ShermanB.M.Absorption of recombinant human growth hormone (rhGH) following intraperitoneal instillation.Perit Dial Int1989; 9: 91–3.
2.
ReddingiusR.E., SchröderC.H., MonnensL.A.H.Intraperitoneal administration of erythropoietin in children on continuous ambulatory peritoneal dialysis.Eur J Pediatr1992; 151: 540–2.
3.
ReddingiusR.E., SchröderC.H., KosterA.M., MonnensL.A.H.Pharmacokinetics of recombinant human erythropoietin in children treated with continuous ambulatory peritoneal dialysis.Eur J Pediatr1994; 153: 850–4.
4.
ReddingiusR.E., De BoerA.W., SchröderC.H., WillemsJ.L., MonnensL.A.H.Increase of the bioavailability of intraperitoneal erythropoietin in children on peritoneal dialysis by administration in small dialysis bags.Perit Dial Int1997; 17: 467–70.
5.
StruijkD.G., KoomenG.C.M., KredietR.T., AriszL.Accuracy of erythropoietin determination in the dialysate of CAPD patients.Adv Perit Dial1990; 6: 289–91.
6.
HunterW.M., GreenwoodF.C.Preparation of iodine-131-labelled human growth hormone of high specific activity.Nature1962; 194: 495–6.
7.
JohnsonC.A., AmidonG., ReichertJ.E., PorterW.R.Adsorption of insulin to the surface of peritoneal dialysis solution containers.Am J Kidney Dis1983; 3: 224–8.
8.
WideröeT-E, SmebyL.C., BergK.J., JörstadS., SvartåsT.M.Intraperitoneal (125I) insulin absorption during intermittent and continuous peritoneal dialysis.Kidney Int1983; 23: 22–8.
9.
TwardowskiZ.J., NolphK.D., McGaryT.J., MooreH.L., CollinP., AusmanR.K.Insulin binding to plastic bags: A methodological study.Am J Hosp Pharm1983; 40: 575–9.
10.
TwardowskiZ.J.Insulin adsorption to peritoneal dialysis bags.Perit Dial Bull1983; 3: 113–16.
