Recombinant human growth hormone (rhGH) was instilled intra peritoneally (i.p.) in six children undergoing continuous cycling peritoneal dialysis {CCPD). Immediate absorption was noted with either 0.250 mg/kg, 0.125 mg/kg, or 0.050 mg/kg of rhGH. Peak serum growth hormone {GH) levels occurred 4 and 8 h following i.p. administration, and the serum GH levels had returned to baseline values at 24 h. In one patient, a higher dosage demonstrated adequate absorption, whereas the lower dosage produced a flat absorption curve. These data indicate that daily i.p. administration of rhGH could be utilized in clinical trials directed toward improving the growth velocity of children undergoing CCPD.
ScharerK., GilliG.Growth in children with chronic renal insufficiency In: FineR.N., GruskinA., eds. Endstage renal disease in children.Philadelphia: W.B. Saunders; 1984: 172–290.
2.
FineR.N.Growth in children with renal insufficiency In: NissensonA.R., FineR.N., GentileD.E., eds. Clinical dialysis.Norwalk: Appleton-Century -Crofts; 1984: 661–670.
3.
KleinknechtC., BroyerM., GagnadouxM.F.Growth in children treated with long-term dialysis. A study of 76 patients.Adv Nephrol.1980; 9: 133–166.
4.
PotterD.E.Comparison of CAPD and hemodialysis in children. In: FineR.N., ed. Chronic ambulatory peritoneal dialysis (CAPD) and chronic cycling peritoneal dialysis (CCPD) in children.Boston: Martinus Nijhoff Publishing; 1987: 351–356.
5.
Yon LilienT., SaluskyI.B., BoechatI.Five years’ experience with continuous ambulatory or continuous cycling peritoneal dialysis in children.J Pediatr.1987; 111: 513–518.
6.
KochY.H., LippeB.M., ShermanB.M.Accelerated growth following recombinant human growth hormone (rhGH) therapy in continuous cycling peritoneal dialysis (CCPD) and in the renal transplant pediatric patient. (Abstract) Am Soc Transpl Physicians 7th Annual Meeting, May 29-June 1, 1988Chicago, IL.
7.
GuydaH., DeanH.Intermittent versus continuous GH administration in growth hormone deficiency.Pediatr Adolesc Endocr.1987; 16: 61–71.
