We describe a case of pathologic jealousy (Othello syndrome) in a patient with Parkinson disease, which abated after discontinuing amantadine. We indicate that early recognition and treatment of the syndrome in this disease may avert physical violence. We also believe that our report further suggests a link between this specific behavioral disorder and dopaminergic activity. (J Geriatr Psychiatry Neurol 1991;4:157-159).
Mooney HB: Pathologic jealousy and psychochemotherapy. Br J Psychiatry1965;111:1023-1042.
4.
Moskowvitz C. , Moses H., Klawans HL: Levodopa-induced psychosis: A kindling phenomenon . Am J Psychiatry1978 ;135:669-674.
5.
Klawans HL, Margolin DI, Dana N., et al: Supersensitivity to d-amphetamine and apomorphine-induced stereotyped behavior induced by chronic d-amphetamine administration. J Neurol Sci1975;25:283-289.
6.
Klawans HL, Goetz C., Nausieda PA, et al: Levodopa-induced dopamine receptor hypersensitivity. Ann Neurol1977;2:125-129.
7.
Davies WL, Grunert RR, Haff RF, et al: Antiviral activity of l-adamantamine (amantadine). Science1964;144:862-863.
8.
Schwab RS, England AC, Poskanzer DC, Young RR: Amantadine in the treatment of Parkinson's disease. JAMA1969;208:1168-1170.
9.
Kulisevsky J. , Tolosa E.: Amantadine in Parkinson's disease , in Koller WC, Paulson G (eds): Therapy of Parkinson's Disease. New York, Marcel Dekker, 1990, pp 143-160.
10.
Bianchine JR : Drugs for Parkinson's disease, spasticity and acute muscle spasms, in Gilman AG, Goodman LS, Rall TW, Murad F (eds): The Pharmacologic Basis of Therapeutics, 7th ed. New York , Macmillan, 1985, pp 473-490.
11.
Munro A.: Excellent response of pathologic jealousy to pimozide. Can Med Assoc J1984;131:852-853.
