The literature regarding Binswanger's disease is reviewed. Emphasis is placed on reviewing the neuropsychological literature related to Binswanger's disease. In addition, a retrospective analysis was carried out among four groups of subjects (N = 61) who were divided according to the presence or absence of dementia and deep white-matter alterations. A main effect for deep white-matter alterations was found for almost all measures of diastolic and systolic blood pressure. Among the two nondemented groups there was an effect of deep white matter alteration on neuropsychological functioning. Subjects with deep white matter changes performed worse on tests of immediate and delayed recall of a prose passage. Among the two demented groups there were no differences on any of the neuropsychological measures, although subjects with deep white matter alterations exhibited a higher incidence of focal neurologic signs and stroke. We conclude that Binswanger's disease is probably more prevalent than currently appreciated. Also, among clinically nondemented individuals periventricular white-matter alterations may be associated with subtle but definable neuropsychological deficits, and these individuals may be at risk for developing a dementing illness. (J Geriatr Psychiatry Neurol 1990;3:31-40).
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References
1.
Olszewski J. : Subcortical arteriosclerotic encephalopathy . World Neurol1962;3:359-374.
Jellinger K., Neumayer E.: Progressive subcorticale vasculare Encephalopathie Binswanger: Eine klinische neuropathologische Studie. Arch Psychiatr Nervenkr Z GESNeurol1964; 205:523-554.
5.
Tomonaga M., Yamanouchi H., Tohgi H., Kameyana M.: Clinicopathologic study of progressive subcortical vascular encephalopathy (Binswanger type) in the elderly. J Am Geriatr Soc1982;30:524-529.
6.
Biemond A.: On Binswanger's subcortical arteriosclerotic encephalopathy and the possibility of its clinical recognition. Psychiatr Neurol Neurochir1970;73:413-417.
Caplan L., Schoene W.: Clinical features of subcortical arteriosclerotic encephalopathy. (Binswanger's disease). Neurology1978;28:1206-1215.
9.
Janota I.: Dementia, deep white matter disease and hypertension: 'Binswanger's disease '. Psychol Med1981;11:39-48.
10.
Brun A., Englund B.: A white matter disorder in dementia of the Alzheimer type: A pathanatomical study. Ann Neurol1986;19:253-262.
11.
Englund E., Brun A., Gustafson L.: A white-matter disease in dementia of the Alzheimer's type—Clinical and neuropsychological correlates. Int J Geriatr Psychiatry1989;4:87-102.
12.
Babikian V. , Ropper A.: Binswanger's disease: A review. Stroke1987;18:2-12.
13.
Valentine A. , Mosely I., Kendall B.: White matter abnormality in cerebral atrophy: Clinicoradiologic correlations. J Neurol Neurosurg Psychiatry1980;43:139-142.
14.
Goto K., Ishii N., Fukasawa H.: Diffuse white-matter disease in the geriatric population. Radiology1981;141:687-695.
15.
Pullicino P. : Prevalence of Binswanger's disease. Lancet1983;1:939.
16.
Rosenberg G. , Kornfield M., Stovring J., Bicknell J.: Subcortical arteriosclerotic encephalopathy (Binswanger): Computerized tomography. Neurology1979;29:1102-1106.
17.
Loizou L., Kendall B., Marshall J.: Subcortical arteriosclerotic encephalopathy: A clinical and radiological investigation . J Neurol Neurosurg Psychiatry1981;14:294-304.
Lotz P., Ballinger W., Quisling R.: Subcortical arteriosclerotic encephalopathy: CT spectrum and pathological correlation. Am J Neuroradiol1986;7:817-822.
20.
McQuinn BA, O'Leary DH: White matter lucencies on computed tomography, subacute arteriosclerotic encephalophy (Binswanger's disease) and blood pressure. Stroke1987; 18:900-905.
21.
George A., DeLeon M., Gentis C., et al: Leukoencephalopathy in normal and pathologic aging: 1. CT of brain lucencies. Am J Neuroradiol1985;7:561-566.
22.
Sharpel G., Chaudy F., Hindo W.: Magnetic resonance imaging of periventricular hyperintensity in a Veterans Administration Hospital population. Arch Neurol1987;44:725-728.
23.
Hendrie H., Farlow MR, Austrom MG, et al: Foci of increased T2 signal intensity on brain MR scans of healthy elderly subjects. Am Neuroradiol1989;10:703-707.
24.
Brant-Zawadzki M., Fein G., VanDyke C., et al: MR Imaging of the Aging Brain: Patchy white-matter lesions and dementia. Am J Neuroradiol1985;6:675-682.
25.
Awad I., Johnson P., Spetzler R., Hodak J.: Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations. Stroke1986; 17:1090-1097.
26.
Zimmerman R. , Fleming C., Lee B., et al: Periventricular hyper-density as seen by magnetic resonance: Prevalence and significance. Am J Neuroradiol1986;7:13-20.
27.
Kertesz A., Black S., Toker G., et al: Periventricular and subcortical hyperintensities on magnetic resonance imaging—Rims, caps and unidentified bright objects. Arch Neurol1988;45: 404-408.
28.
Frazekas F. , Chawluk A., Hurtig H., Zimmerman R.: MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. Am J Neuroradiol1987;8:421-426.
29.
Braffman BH , Zimmerman RA, Trojanowski JQ, et al: Brain MR: Pathologic correlations with gross histopathology. 2. Hypertensive white-matter foci in the elderly . Am J Neuroradiol1988;9:629-636.
30.
Roman G.: Senile dementia of the Binswanger type. JAMA1987;258:1782-1788.
31.
Kinkel W., Jacobs L., Polachini I., et al: Subcortical arteriosclerotic encephalopathy (Binswanger's disease) with computed tomographic, nuclear, magnetic resonance, and clinical correlations . Arch Neurol1985;42:951-959.
32.
Rao SM, Mittenberg W., Bernardon L., et al: Neuropsychological test findings on subjects with leukoaraiosis . Arch Neurol1989;46:40-47.
33.
Hachinski V. , Potter P., Merskey H.: Leuko-araiosis. Arch Neurol1987;44:21-23.
34.
Gerard A., Weisberg L.: MRI periventricular lesions in adults. Neurology1986;36:998-1001.
35.
Gupta S., Nahudy M., Young J., et al: Periventricular white matter changes and dementia—Clinical, neuropsychological, radiological and pathological correlations. Arch Neurol1988; 45:637-641.
36.
Steingart A. , Hachinski V., Lau C., et al: Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis). Arch Neurol1987;44:32-35.
37.
Steingart A. , Hachinski V., Lau C., et al: Cognitive and neurological findings in demented patients with diffuse white matter lucencies on CT scan (leuko-araiosis) . Arch Neurol1987;44:36-39.
38.
Blessed G., Tomlinson BE, Roth M.: The association between quantitative measures of dementia and of senile changes in the cerebral gray matter of elderly subjects. Br J Psychiatry1968;114:797- 811.
39.
Diagnostic and Statistical Manual of Mental Disorders, 3rd edition revised. Washington, DC, American Psychiatric Association, 1987.
40.
Whelihan W. , Lesher E., Kleban M., Granick S.: Mental status and memory assessment as predictors of dementia. J Gerontol1984;39:572-575.
41.
Lesher E., Whelihan W.: Reliability of mental status instruments administered to nursing home residents . J Consult Clin Psychol1986;54:726- 727.
42.
Wechsler O.: Manual for the Wechsler Adult Intelligence Scale-Revised. New York, Psychological Corporation, 1981.
43.
Hooper HE: Hooper Visual Organization Test. Los Angeles, Western Psychological Services, 1958.
44.
Kaplan E., Goodglass H., Weintraub S.: Boston Naming Test. Philadelphia, Lea & Febiger, 1983.
45.
Yesavage J.: The use of self-rating depression scales in the elderly, in Poon LW (ed): Handbook for Clinical Memory Assessment. Washington, DC, American Psychiatric Association, 1986, pp 312-217.
46.
Mahler M., Cummings J., Tomiyasu U.: Atypical dementia syndrome in an elderly man. J Am Geriatr Soc1987;35:1116-1126.
47.
Albert M., Feldman R., Willis A.: The subcortical dementia of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry1974;27:121-130.
