A case of accidental anti-flea preparation (lufenuron) ingestion by a breastfeeding mother is reported. An estimation of infant exposure level was calculated based on the highest level measured. The breastfed infant was exposed to an average lufenuron dose of 0.032 mg/kg/day, which is only 3% of a reported acute overdose. No adverse effects were reported during 7 months of follow-up. Breastfeeding should be considered cautiously after consultation with a regional poison center in cases of accidental ingestion of this drug by a breastfeeding mother. The infant should be monitored for potential adverse effects.
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MacKichan J. Pharmacokinetics and Dose Proportionality of Lufenuron in Male Beagles, Pregnant vs. Non-Pregnant Beagles and Beagle Pups. Kalamazoo, Mich: Ciba Animal Health, Ciba-Geigy Corp; 1997.
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Maurer MP, Baitotti A. Determination of Racemic Lufenuron (CGA 184699) in Blood Samples of Cats and Dogs by High Performance Liquid Chromatography.St. Aubin, Switzerland: Novartis Centre de Receherches Animale.
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