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Abstract

To realize the photothermal therapy ability of Prussian blue-modified ferritin nanoparticles (PB-Ft NPs) and its synergistic effect with chemotherapy, PB-Ft NPs were synthesized by a simple surface double decomposition reaction. Mean sizes of ferritin and PB-Ft NPs were 10.4 nm and 12.6 nm, respectively. The obtained PB-Ft NPs were verified to have both the photothermal conversion ability of Prussian blue and the morphology of ferritin. The in vitro and in vivo photothermal therapy results confirm PB-Ft NPs can successfully inhibit the growth of murine breast cancer cell line (4T1) without any obvious side effect. Moreover, taking use of the peroxidase-like activity of PB-Ft NPs, the photothermal therapy effect of PB-Ft NPs effectively improved the curative effect of gemcitabine (GEM) via enhancing reactive oxygen species production. The obtained PB-Ft NPs can be served as a useful and safe photothermal therapy agent in breast cancer. Moreover, PB-Ft NPs-assisted photothermal therapy can be applied as an adjunctive therapy with various established cancer treatments such as chemotherapy.

Keywords

Prussian blue photothermal therapy ferritin gemcitabine reactive oxygen species adjunctive therapy

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References

Roussakow

Where, when and why hyperthermia went wrong way?

Oncothermia J 2013; 7: 190–231.

Jiang

Luo

Men

et al . Red blood cell membrane-camouflaged melanin nanoparticles for enhanced photothermal therapy. Biomaterials 2017; 143: 29.

Qian

Cao

Long

YT.

Binary system for microRNA-targeted imaging in single cells and photothermal cancer therapy. Anal Chem 2016; 88: 8640–8647.

Wang

Liang

et al . Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with Anti-CTLA-4 therapy to inhibit cancer metastasis. Adv Mater 2014; 26: 8154–8162.

Rashidi

Yao

et al . CuS nanoagents for photodynamic and photothermal therapies: phenomena and possible mechanisms. Photodiagnosis Photodyn Ther 2017; 19: 5.

Zhang

et al . A novel Met-IR-782 near-infrared probe for fluorescent imaging-guided photothermal therapy in breast cancer. Lasers Med Sci 2018; 33: 1601–1608.

Chen

Liang

Wang

et al . An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery. Biomaterials 2014; 35: 9355–9362.

Liu

Feng

et al . Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy. Chem Commun (Camb) 2012; 48: 11567–11569.

Liu

et al . Magnetic Prussian blue nanoparticles for targeted photothermal therapy under magnetic resonance imaging guidance. Bioconjugate Chem 2014; 25: 1655.

10.

Cheng

Gong

Zhu

et al . PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy. Biomaterials 2014; 35: 9844–9852.

11.

Yin

et al . Prussian blue as a highly sensitive and background-free resonant Raman reporter. Anal Chem 2017; 89: 1551–1557.

12.

Zhang

Yin

J-J

et al . Prussian blue nanoparticles as multienzyme mimetics and reactive oxygen species scavengers. J Am Chem Soc 2016; 138: 5860–5865.

13.

Maeda

Sawa

et al . Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000; 65: 271–284.

14.

Natfji

Ravishankar

Hmi

et al . Parameters affecting the enhanced permeability and retention effect: the need for patient selection. J Pharm Sci 2017; 106: 3179–3187.

15.

Cai

Cao

et al . Enhanced magnetic resonance imaging and staining of cancer cells using ferrimagnetic H-ferritin nanoparticles with increasing core size. Int J Nanomedicine 2015; 10: 2619.

16.

Han

Seaman

et al . Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. Plos One 2011; 6: e23800.

17.

Paragas

Ned

et al . Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell 2009; 16: 35–46.

18.

Yan

Zhang

Yang

et al . Therapeutic upregulation of Class A scavenger receptor member 5 inhibits tumor growth and metastasis. Cancer Sci 2012; 103: 1631.

19.

Turino

Ruggiero

Stefania

et al . Ferritin decorated PLGA/Paclitaxel loaded nanoparticles endowed with an enhanced toxicity towards MCF-7 breast tumour cells. Bioconjugate Chem 2017; 28: 1283–1290.

20.

Conti

Lanzardo

Ruiu

et al . L-Ferritin targets breast cancer stem cells and delivers therapeutic and imaging agents. Oncotarget 2016; 7: 66713–66727.

21.

Crich

Cadenazzi

Lanzardo

et al . Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells. Nanoscale 2015; 7: 6527–6533.

22.

Goodall

Johnson

Wood

Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: a multicentric 2004 national PHRC study. Int J Cancer 2012; 131: 426–437.

23.

Zhang

Chen

et al . Prussian blue modified ferritin as peroxidase mimetics and its applications in biological detection. J Nanosci Nanotech 2013; 13: 60–67.

24.

Zhang

et al . Prussian blue nanoparticles possess potential anti-inflammatory properties via scavenging reactive oxygen species. Inflamm Cell Signal 2016; 3: e1342.

25.

Han

Heo

et al . Metabolic characterization of imatinib-resistant BCR-ABL T315I chronic myeloid leukemia cells indicates down-regulation of glycolytic pathway and low ROS production. Leuk Lymphoma 2016; 57: 2180–2188.

26.

Sanchez-Sanchez

Gutierrez-Herrero

Lopez-Ruano

et al . NADPH oxidases as therapeutic targets in chronic myelogenous leukemia. Clin Cancer Res 2014; 20: 4014–4025.

27.

Zhang

Gong

Zhang

et al . Prussian blue modified iron oxide magnetic nanoparticles and their high peroxidase-like activity. J Mater Chem 2010; 20: 5110–5116.

28.

Stockwin

Han

BS.

Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction. Int J Cancer 2010; 127: 1266–1275.

29.

Chen

Wang

Huang

et al . Prussian blue with intrinsic heme-like structure as peroxidase mimic. Nano Res 2018; 11: 4905–4913.

30.

Abdelwahed

Degobert

Stainmesse

et al . Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev 2006; 58: 1688–1713.

31.

Terashima

Uchida

Kosuge

et al . Human ferritin cages for imaging vascular macrophages. Biomaterials 2011; 32: 1430–1437.

32.

Kosuge

Sherlock

Kitagawa

et al . Near infrared imaging and photothermal ablation of vascular inflammation using single-walled carbon nanotubes. J Am Heart Assoc 2012; 1: e002568.

33.

Zhang

Goncalves

Mosser

DM.

The isolation and characterization of murine macrophages. Curr Protoc Immunol 2008; 83: 14.11.11–14.11.14.

34.

Weischenfeldt J and Porse B. Bone marrow-derived macrophages (BMM): isolation and applications. Cold Spring Harb Protoc 2008; 3: 1--6.

35.

Wang

Rykov

et al . Prussian blue/TiO2 nanocomposites as a heterogeneous photo-Fenton catalyst for degradation of organic pollutants in water. Catal Sci Technol 2015; 5: 504–514.

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Prussian blue-modified ferritin nanoparticles for effective tumor chemo-photothermal combination therapy via enhancing reactive oxygen species production

Abstract

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