Magnetic,fluorescent,and thermo-responsive poly(MMA-NIPAM-Tb(AA) 3 Phen)/Fe 3 O 4 multifunctional nanospheres prepared by emulsifier-free emulsion polymerization

Abstract

Magnetic, luminescent, and thermoresponsive multifunctional nanospheres composed of modified Fe₃O₄ nanoparticles as the core and rare earth complex Tb(AA)₃Phen as the shell are synthesized by emulsifier-free emulsion polymerization. The core–shell spherical structure has a size between 140 and 220 nm and exhibits strong green fluorescence of the rare earth complex Tb(AA)₃Phen. In the R₂ relaxivity and in vivo MRI studies, the R₂ relaxivity of the nanospheres is 562.56 mM^–1 s^–1 and enhanced T₂-weighted images are observed from the nanospheres in the liver and spleen after injection as a contrast agent. The excellent superparamagnetic, thermosensitive, and fluorescent properties render the nanospheres useful in biomedical engineering and optical imaging.

Keywords

Luminescence magnetic properties nanostructure rare earth

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References

Howes

Green

Bowers

. Magnetic conjugated polymer nanoparticles as bimodal imaging agents. J Am Chem Soc 2010; 132: 9833–9833.

Zhang

Gao

. Multifunctional nanocomposites of superparamagnetic (Fe₃O₄) and NIR-responsive rare earth-doped up-conversion fluorescent (NaYF₄:Yb, Er) nanoparticles and their applications in biolabeling and fluorescent imaging of cancer cells. Nanoscale 2010; 2: 1141–1141.

Lehmann

Parak

Zhang

. Fluorescent-magnetic hybrid nanoparticles induce a dose-dependent increase in proinflammatory response in lung cells in vitro correlated with intracellular localization. Small 2010; 6: 753–753.

Erogbogbo

Yong

. Biocompatible magnetofluorescent probes: luminescent silicon quantum dots coupled with superparamagnetic Iron(III) oxide. ACS Nano 2010; 4: 5131–5131.

Kang

. Ultrastable, highly fluorescent, and water-dispersed silicon-based nanospheres as cellular probes. Angew Chem Int Ed 2009; 48: 128–128.

Gonzalez-Fernandez

Torres

Andr-Verg

. Magnetic nanoparticles for power absorption: optimizing size, shape and magnetic properties. J Solid State Chem 2009; 182: 2779–2779.

Grasset

Dorson

Molard

. Haneda Chem Commun 2009; 40: 4729–4729.

Zhao

. Synthesis and characterization of multi-functional nanoparticles possessing magnetic, up-conversion fluorescence and bio-affinity properties. J Mater Chem 2004; 14: 1336–1336.

Deng

Yang

Wang

. A novel approach for preparation of thermoresponsive polymer magnetic microspheres with core--shell structure. Adv Mater 2003; 15: 1729–1729.

10.

Guo

Yang

Wang

. Poly(N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres: preparation, characterization, and biomedical applications. Chem Mater 2006; 18: 5554–5554.

11.

Deng

Wang

Shen

. Preparation, characterization, and application of multistimuli-responsive microspheres with fluorescence-labeled magnetic cores and thermoresponsive shells. Chem Eur J 2005; 11: 6006–6006.

12.

Jin

Gao

. Plasmonic fluorescent quantum dots. Nat Nanotechnol 2009; 4: 571–571.

13.

Gupta

. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005; 26: 3995–4021.

14.

Dosev

Nichkova

. Synthesis and bio-functionalization of multifunctional magnetic Fe₃O₄@Y₂O₃:Eu nanocomposites. J Mater Chem 2009; 19: 4695–4695.

15.

Kievit

Zhang

. Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers. Adv Mater 2011; 23: H217–H217.

16.

Zhang

Pan

Teng

. Bifunctional magnetic-luminescent nanocomposites: Y₂O₃/Tb Nanorods on the Surface of Iron Oxide/Silica Core--Shell Nanostructures. J Phys Chem C 2008; 112: 9623–9623.

17.

Dulkeith

Morteani

Niedereichholz

. Fluorescence quenching of dye molecules near gold nanoparticles: radiative and nonradiative effects. Phys Rev Lett 2002; 89: 203002–203002.

18.

Zhu

Tao

Wang

. Magnetic, fluorescent, and thermo-responsive Fe₃O₄/rare earth incorporated poly(St-NIPAM) core--shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probes. Biomaterials 2013; 34: 2296–2296.

19.

Yan

. Synthesis and characterization of photoluminescent terbium-containing polymer precursors. J Photochem Photobiol A 2009; 204: 19–19.

20.

Zhu

Shang

Wang

. Fluorescent Magnetic Fe₃O₄/Rare Earth Colloidal Nanoparticles for Dual-Modality Imaging. Small 2013; 9: 2991–2991.

21.

Huang

. Ultrasonic spray pyrolysis synthesis of porous Bi2WO6 microspheres and their visible-light-induced photocatalytic removal of NO. J Phys Chem C 2010; 114: 6342–6342.

22.

Zhao

. Preparation and characterization of graphite nanosheets decorated with Fe₃O₄ nanoparticles used in the immobilization of glucoamylase. Carbon 2012; 50: 2976–2976.

23.

Dong

. Electrospinning preparation and properties of Fe₃O₄/Eu(BA)3phen/PVP magnetic-photoluminescent bifunctional composite nanofibers. J Nanopart Res 2012; 14: 1203–1203.

24.

Dong

. Electrospinning fabrication and properties of Fe₃O₄/Eu(BA)3phen/PMMA magnetic -photoluminescent bifunctional composite nanoribbons. Opt Mater 2013; 35: 526–526.

25.

Luo

Song

Zhang

. Multi-functional thermosensitive composite microspheres with high magnetic susceptibility based on magnetite colloidal nanoparticle clusters. Langmuir 2010; 26: 1674–1674.

26.

Hao

Xing

. Magnetic nanoparticles in MR imaging and drug delivery. Adv Mater 2010; 22: 2729–2729.

27.

Sun

Lee

JSH

Zhang

. Magnetic nanoparticles in MR imaging and drug delivery. Drug Deliv Rev 2008; 60: 1252–1252.

28.

Stephen

Kievit

Zhang

. Magnetite nanoparticles for medical MR imaging. Mater Today 2011; 14: 330–330.

29.

Sun

Fang

. PEG-Mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo. ACS Nano 2010; 4: 2402–2402.

30.

Weissleder

Stark

Engelstad

. Superparamagnetic iron oxide:pharmacokinetics and toxicity. Am J Roentgenol 1989; 152: 167–167.

31.

Caravan

Ellison

McMurry

. Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev 1999; 99: 2293–2293.

32.

Cheng

Yang

. Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. Angew Chem Int Edit 2011; 50: 7385–7385.