A new method for the dissolution of chitosan in an aqueous medium using polyoxyethylene diacid was developed. Films cast from these solutions were found to swell reversibly. The effect of polyether content and pH on the swelling behavior of the films was studied. Monolayer type devices for drug release applications were prepared using 8-hydroxy-7-iodoquinoline-5-sulfonic acid as a model drug.
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References
1.
1. Domard, A.1987. Int. J. Biol. Macromol., 9:98.
2.
2. Roberts, G. A. F.1992. In Chitin Chemistry, Houndmills, Basingstoke, Hampshire: Macmillan Press Ltd., p. 278.
3.
3. Muzarelli, R., V. Baldassare, F. Conti, P. Ferrara and G. Biagini. 1988. Biomaterials, 9:247.
4.
4. Hirano, S., H. Seino, Y. Akiyama and I. Nonaka. 1990. Progress in Biomedical Polymers, C. G. Gebelein and R. L. Dunn, eds., New York: Plenum Press, p. 283.
5.
5. Hirano, S., H. Seino, Y. Akiyama and I. Nonaka. 1988. Polym. Mat. Sci. Eng., 59:897.
6.
6. Brine, C. J., P. A. Sandford and J. P. Zikakis. 1992. "Advances in Chitin and Chitosan,"Proc. 5th Inter. Conf Chitin and Chitosan, London: Elsevier Applied Science.
7.
7. Pratan Laboratories Inc.1987. Chitin and Chitosan-General Properties and Applications, PLI-002. WARendmond.
8.
8. Dunn, Q., E. T. Li, E. W. Grandmaison and M. F. A. Goosen. 1992. J. Bioact. Compatible Polymers, 7:370.
9.
9. Olsen, R. A., D. Swartzmiller, W.W. Weppner and R. Winandy. 1989. "Chitin and Chitosan,"Proc. 4th Intern. Confi Chitin and Chitosan, G. Skjak-Braek, T. Anthonsen and P. Standford, eds., London: Elsevier Applied Science Publishers, p. 51.
10.
10. Sanford, P. 1989. "Chitin and Chitosan,"Proc. 4th Int. Conf Chitin and Chitosan, G. Skjak-Brack, T. Anthonsen and P. Standford, eds., London: Elsevier Applied Science Publishers, p. 51.
11.
11. Nagai, T., Y. Sawayanagi and N. Nambu. 1984. Chitin, Chitosan and Released Enzymes, Orlando: Academic Press, p. 21.
12.
12. Sawayanagi, Y., N. Nambu and T. Nagai. 1982. Chem. Pharm. Bull., 30:4213.
13.
13. Miyazaki, S., K. Ishii and T. Nadai. 1981. Chem. Pharm. Bull., 29:3067.
14.
14. Hirano, S.1989. Jpn. J. Med. Instrum., 59:134.
15.
15. Miyazaki, S., H. Yamagushi, C. Yokoguchi, M. Takada and W. Hon. 1988. J. Pharm. Pharmacol., 40:642.
16.
16. Nishioka, Y., S. Kyotani, M. Okamura, M. Miyazaki, K. Okazaki, S. Ohnishi, Y. Yamomoto and K. Ito. 1990. Chem. Pharm. Bull., 38:2871.
17.
17. Nishioka, Y., S. Kyotani, M. Okamura, M. Miyazaki, Y. Sakamoto, M. Morita and K. Okazaki. 1992. Chem. Pharm. Bull., 40:267.
18.
18. Bonvin, M. M. and M. M. deBertorello. 1993. Polym. Bull., 31:375.
19.
19. Angelova, N., N. Manolova, I. Reshow, V. Maxim ova, S. Bog ANOVA and A. Domard. 1995. J. Bioact. Biocompatible Polymer, 10:285.
20.
20. Ferruti, P., M. C. Tansi, L. Rusconi and R. Cecchi. 1981. Makromol. Chem., 182:2183.
21.
21. Wrzyszczynski, A., Xia Qu, L. Szosland, E. Adamczak, L. A. Linde and J. F. Rabek. 1995. Polym. Bull., 34:493.
