Poly(ε-caprolactone) [poly(CL)] latexes and poly(D,L-lactide) [poly(D,L-Lc)] microspheres were prepared directly by ring-opening precipita tion polymerization carried out in heptane-dioxane (4:1 v/v) mixed solvent in the presence of poly(dodecyl acrylate)-g-poly(ε-caprolactone) used as the surface active agent. This designed synthetic method yielded latexes and microspheres with narrow size distribution; poly(CL) latex Dv/Dn = 1.038 and for poly(D,L- Lc) microspheres Dv/Dn = 1.15. (Dv and Dn denote the volume and number average diameters of particles.) The poly(CL) latex, synthesized by using CH3CH2OAl(CH2CH3) 2 as initiator, had a narrow polymer polydispersity of 1.11. Poly(D,L-Lc) microspheres, besides polymer with Mw/M n = 1.05 contained some unreacted lactide. Adsorption of human serum albumin and human gamma globulins on both kinds of polyester particles was studied for their potential use as polypeptide and protein delivery systems.
Get full access to this article
View all access options for this article.
References
1.
Penczek, S., J. Fejgin, W. Sadowska and M. Tomaszewicz.1968. Makromol. Chem., 116:203.
2.
Mason, N.S., C.S. Miles and R.E. Sparks.1981. In Biomedical and Dental Applications of Polymers, Ch. G. Gebelein and F. F. Koblitz, eds., New York, NY, London: Plenum Press, p. 279.
3.
Eling, B., S. Gogolewski and A.J. Pennings.1982. Polymer,23:1587.
4.
Hyon, S.-H., K. Jamashidi and Y. Ikada.1984. In Polymers as Biomaterials, S. W. Shalaby, A. S. Hoffman , B. D. Ratner and T. A. Horbett, eds., New York, NY, London: Plenum Press, p. 51.
5.
Jarrett, P., C.V. Benedict, J.P. Bell, J.A. Cameron and S.J. Huang.1984. In Polymers as Biomaterials, S. W. Shalaby, A. S. Hoffman , B. D. Ratner and T. A. Horbett, eds., New York, NY, London: Plenum Press, p. 181.
6.
Leenslag, J.W. , S. Gogolewski and A.J. Pennings.1984. J. Appl. Polym. Sci., 29:2829.
7.
Kitchel, J.P. and D.L. Wise.1985. Methods in Enzymol. , 112:436.
8.
Hutchinson, F.G. and B.J.A. Furr.1987. In Drug Delivery Systems, Fundamentals and Techniques, P. Johnson and J. G. Lloyd-Jones, eds., Weinheim: VCH, 106.
9.
Cohn, D. and H. Younes.1988. J. Biomed. Mater. Res., 22:993.
10.
McGinity, J.W.1990. ACS Polym. Prep., 31(2):187.
11.
Migliaresi, C., A. De Lollis, L. Fambri and D. Cohn.1991. In Polymers in Medicine-4, C. Migliaresi, E. Chiellini, P. Giusti and L. Nicolais, eds., New York, NY, London: Elsevier, p. 111.
12.
Barrows, T.H.1991. In High Performance Biomaterials, A Comprehensive Guide to Medical and Pharmaceutical Applications, M. Szycher, ed., Lancaster, Basel: Technomic Publishing Company, Inc., p. 243.
13.
Linhardt, R.J.1989. In Controlled Release of Drugs: Polymers and Aggregate Systems, M. Rosoff, ed., New York, NY: VCH Publishers, p. 53.
14.
Benoit, J.P. and F. Puisieux.1986. In Polymeric Nanoparticles and Microspheres , P. Guiot and P. Couvreur, eds., Boca Raton, FL: CRC Press, p. 137.
15.
Gebelein, Ch. G., M. Chapman and T. Mirza.1987. In Applied Bioactive Polymeric Materials, Ch. G. Gebelein, Ch. E. Carraher, Jr. and V. R. Foster, New York, NY: Plenum Press, p. 151.
16.
Wang, P.Y. and E. Kothe.1987. In Applied Bioactive Polymeric Materials , Ch. G. Gebelein, Ch. E. Carraher, Jr. and V. R. Foster, New York, NY: Plenum Press, p. 75.
17.
Thies, C.1989. In Controlled Release of Drugs: Polymers and Aggregate Systems, M. Rosoff, ed., New York, NY: VCH Publishers, p. 97.
18.
Gabelnick, H.L.1990. ACS Polym. Prep., 31(2):184.
19.
Tice, T.R., F. Labrie, A. McRae-Deguerce, D.L. Dillon, D.W. Mason and R.M. Gilley.1990. ACS Polym. Prep., 31(2):185.
20.
Dunn, R.L., A.J. Tipton, G.L. Yewey, P.C. Reinhart, E.M. Menardi, J.A. Rogers and G.L. Southard.1990. ACS Polym. Prep., 31(2):189.
21.
Cohen, S., A. Cochrane, E. Nardin and R. Langer.1992. ACS Polym. Mat. Sci. Eng., 66:91.
22.
Dubois, Ph. , C. Grandfils, R. Jérôme and Ph. Teyssié.1991. ACS Polym. Prep., 31(1):449.
23.
Flandroy, P. , C. Grandfils, J. Collington, A. Thibaut, N. Nihant, S. Barbette, R. Jérôme and Ph. Teyssié.1990. Neuradiology, 32:311.
24.
Tabata, Y. and Y. Ikada.1990. Adv. Polym. Sci., 94:107.
25.
Tabata, Y. and Y. Ikada.1991. In High Performance Biomaterials, A Comprehensive Guide to Medical and Pharmaceutical Applications, M. Szycher, ed., Lancaster, Basel: Technomic Publishing Company, Inc. , p. 621.
26.
Tice, T.R. and R.M. Gilley.1985. J. Controlled Rel., 2:343.
27.
Union Carbide.1972. U.S. patent 3,632,669.
28.
Ito, K., Y. Hashizuka and Y. Yamashita.1977. Macromolecules,10:821.
29.
Ito, K. and Y. Yamashita.1978. Macromolecules,11:68.
30.
Ouhadi, T., C. Stevens and Ph. Teyssié .1975. Makromol. Chem., Suppl., 1:191.
31.
Hamitou, A., T. Ouhadi, R. Jérôme and Ph. Teyssié .1977. J. Polym. Sci., Polym. Chem. Ed., 15:865.
32.
Cherdron, H. , H. Ohse and F. Korte.1962. Makromol. Chem., 56:187.
33.
Slomkowski, S.1985. Makromol. Chem., 186:2581.
34.
Hofman, A., S. Slomkowski and S. Penczek.1987. Makromol. Chem., Rapid Commun., 8:387.
35.
Duda, A., Z. Florjanczyk, A. Hofman, S. Slomkowski and S. Penczek.1990. Macromolecules,23:1640.
36.
Duda, A. and S. Penczek.1991. Makromol. Chem., Macromol. Symp., 42/43:135.
37.
Duda, A. and S. Penczek.1991. Makromol. Chem., Macromol. Symp., 47:127.
38.
Penczek, S. , A. Duda and S. Slomkowski.1992. Makromol. Chem., Macromol. Symp., 54/55:31.
39.
Penczek, S. and A. Duda.1993. Makromol. Chem., Macromol. Symp., 67:222.
40.
Dubois, Ph. , R. Jérôme and Ph. Teyssié.1989. Polym. Bull., 22:475.
41.
Dubois, Ph. , R. Jérôme and Ph. Teyssié.1991. MakromoL Chem., Macromol. Sym., 42/43:103.
42.
Dubois, Ph. , R. Jérôme and Ph. Teyssié.1991. Macromolecules, 24:977.
43.
Dubois, Ph. , Ph. Degée, R. Jérôme and Ph. Teyssié.1993. Macromolecules, 26:2730.
44.
Sosnowski, S., S. Slomkowski, S. Penczek and L. Reibel.1983. Makromol. Chem., 184:2159.
45.
Holten, C.H. , A. Muller and D. Rechbinder.1971. Lactic Acid. Weinheim : Verlag Chemie, p. 221.
46.
Sosnowski, S., S. Slomkowski, S. Penczek and Z. Florjanczyk.1991. Makromol. Chem. , 192:1457.
47.
Duda, A.1994. Macromolecules,27:576.
48.
Tunc, D.C., W.M. Rohovsky, B. Jadhav, W.B. Lehman, A. Strongwater and F. Kummer.1987. In Advances in Biomedical Polymers, Polymer Science Technology, Vol. 35, C. G. Gebelein, ed., New York, NY: Plenum Press, pp. 87.
49.
Leenslag, J.W. and A.J. Pennings.1987. J. Makromol. Chem. , 188:1809.
50.
Jamshidi, K. , R.C. Eberhart, S.-H. Hyon and Y. Ikada.1987. ACS Polym. Prep., 28(1):236.
51.
Duda, A. and S. Penczek.1990. Macromolecules,23:1636.
52.
Slomkowski, S. and T. Basinska.1992. In Polymer Latexes Preparation, Characterization and Applications, ACS Symp. Ser. 492 , E. S. Daniels, E. D. Sudol and M. S. El-Aasser, eds., Washington, DC: ACS, p. 328.
53.
Lowry, D.H., N.J. Rosenbrough, A.L. Farr and R.J. Randall.1951. J. Biochem.,193:265.
54.
Andrade, J.D. and V. Hlady.1986. Adv. Polym. Sci., 79:1.
55.
Lundstrom, I., B. Ivarsson, U. Jönsson and H. Elving.1987. In Polymer Surfaces and Interfaces , W. J. Feast, H. S. Munro , eds., New York, NY: J. Wiley , p. 201.
