Derivatives of 5-flurorouracil 1-N-p-vinylbenzoyl-5-fluorouracil (VBFU) were prepared and the solvolysis rates were determined and compared with other 1-N-substituted 5-fluorouracils. VBFU was homopolymerized and copolymerized with maleic anhydride or poly(ethylene glycol) macromonomer. The hydrolysis of these polymeric drugs was studied in a phosphate buffer solu tion, and in vivo antitumor activity was evaluated using Ehrlich's ascites or Sarcoma 180 tumor-bearing mice.
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