UV rays are one of the most dangerous factors that harm the skin. There is continuous improvement in getting an effective sunscreen that protects the skin from excessive exposure to UV rays. Typically, phenylbenzimidazole-5-sulfonic acid (PBSA) is used as a sun blocking agent, but its disadvantage is that it can photodegrade and cause cell damage. In our work, PBSA was encapsulated in niosomes nanoparticles then coated with chitosan-aloe vera (CS-nio-aloe/PBSA) to form a carrier polymer with novel and potent properties. This polymer controls PBSA release and epidermal penetration. Characterization of CS-nio-aloe/PBSA polymer nanoparticles through transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and dynamic light scattering (DLS). The carrier polymer release rate was studied in vitro and epidermal permeability to coated PBSA was assessed using mouse skin. The nanoparticle polymer containing sunscreen was effectively prepared with an encapsulation efficiency of 80%. The formulation (CS-nio-aloe/PBSA) was completely deposited on the surface of the skin. This supports its use to protect the skin, and its nanostructures stimulate the release of PBSA for a longer period. Encapsulation of PBSA in CS-nio-aloe nanoparticles could allow for further cellular preservation, UV protection, control of free PBSA, and limited penetration through the mouse skin epidermis.
JuzenieneAMoanJ. Beneficial effects of UV radiation other than via vitamin D production. Dermatoendocrinol2012; 4(2): 109–117.
2.
LimJLSternRS. High levels of ultraviolet B exposure increase the risk of non-melanoma skin cancer in psoralen and ultraviolet A-treated patients. J Investig Dermatol2005; 124: 505–513.
FoyerCHLelandaisMKunertKJ. Photooxidative stress in plants. Physiol Plant1994; 92: 696–717.
5.
RosetteCKarinM. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science1996; 274: 1194–1197.
6.
YagerJ. The skin as an immune organ. In: IhrkePJMasonISWhiteSD (eds) Advances in veterinary dermatology. Oxford: Pergamon Press, 1993, pp.31.
7.
Gordon SprattEACarucciJA. Skin cancer in immunosuppressed patients. Facial Plast Surg2013; 29: 402–410.
PugliaCDamianiEOffertaA, et al. Evaluation of nanostructured lipid carriers (NLC) and nanoemulsions as carriers for UV-filters: characterization, in vitro penetration and photostability studies. Eur J Pharm Sci2014; 51: 211–217.
10.
SerponeNDondiDAlbiniA. Inorganic and organic UV filters: their role and efficacy in sunscreens and suncare products. Inorganica Chim Acta2007; 360: 794–802.
11.
MutalikSShettyPKVenuvankaV, et al. Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity. Int J Nanomed2015; 10: 6477–6491.
12.
HaydenCGCrossSEAndersonC, et al. Sunscreen penetration of human skin and related keratinocyte toxicity after topical application. Skin Pharmacol Physiol2005; 18: 170–174.
13.
LiuXGriceJELademannJ, et al. Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man. Br J Clin Pharmacol2011; 72: 768–774.
14.
HaydenCGRobertsMSBensonHA. Systemic absorption of sunscreen after topical application. Lancet1997; 350: 863–864.
15.
BastienNMillauJFRouabhiaM, et al. The sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid photosensitizes the formation of oxidized guanines In cellulo after UV-A or UV-B exposure. J Investig Dermatol2010; 130: 2463–2471.
16.
TampucciSBurgalassiSChetoniP, et al. Cutaneous permeation and penetration of sunscreens: formulation strategies and in vitro methods. Cosmetics2018; 5: 1.
17.
InbarajJJBilskiPChignellCF. Photophysical and photochemical studies of 2-phenylbenzimidazole and UVB Sunscreen 2-phenylbenzimidazole-5-sulfonic Acid. Photochem Photobiol2002; 75(2): 107–116.
18.
SunilkumarMRNesalinJAJManiT. Development and evaluation of niosomes containing ketoconazole. World J Pharm Pharm Sci2016; 5(02): 1318–1327.
19.
MohamadEAFahmyHM. Niosomes and liposomes as promising carriers for dermal delivery of annona squamosa extract. Braz J Pharm Sci2020; 56: e18096.
20.
PaolicelliPde la FuenteMSánchezA, et al. Chitosan nanoparticles for drug delivery to the eye. Expert Opin Drug Deliv2009; 6: 239–253.
21.
DavoudiZRabieeMHoushmandB, et al. Development of chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis. Drug Dev Ind Pharm2018; 44: 40–55.
22.
KanaJRMeimandipourA. Antimicrobial activity of chitosan film forming solution enriched with essential oils; an in vitro assay. Iran J Biotechnol2017; 15(2): 111–119.
23.
CesarVJozićIBegovićL, et al. Cell-Type-Specific modulation of hydrogen peroxide cytotoxicity and 4-hydroxynonenal binding to human cellular proteins in vitro by antioxidant Aloe vera extract. Antioxidants2018; 7(10): 125.
24.
MohamadEAAlyAAKhalafAA, et al. Evaluation of natural bioactive-derived punicalagin niosomes in skin-aging processes accelerated by oxidant and ultraviolet radiation. Drug Des Dev Ther2021; 15: 3151–3162.
25.
GulatiMGroverMSinghM, et al. Study of azathioprine encapsulation into liposomes. J Microencapsul1998; 15: 485–494.
26.
CalvoPVila-JatoJLAlonsoMJ. Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers. Int J Pharm1997; 153: 41–50.
27.
MonemASSayedFAZRagehMM, et al. Cytotoxicity and genotoxicity of gold nanorods assisted photothermal therapy against Ehrlich carcinoma in vivo. Life Sci2020; 257: 118108.
28.
HenriksenISandeSASmistadG, et al. In vitro evaluation of drug release kinetics from liposomes by fractional dialysis. Int J Pharm1995; 119: 231–238.
29.
SternRS. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol2001; 44: 755–761.
30.
WangHRChenKM. Preparation and surface active properties of biodegradable dextrin derivative surfactants. Colloids Surf A Physicochem Eng Asp2006; 281: 190–193.
31.
López AnguloDEdo Amaral SobralPJ. Characterization of gelatin/chitosan scaffold blended with aloe vera and snail mucus for biomedical purpose. Int J Biol Macromol2016; 92: 645–653.
32.
Nejatzadeh-BarandoziFEnferadiST. FT-IR study of the polysaccharides isolated from the skin juice, gel juice, and flower of Aloe vera tissues affected by fertilizer treatment. Org Med Chem Lett2012; 2: 33.
33.
LimZXCheongKY. Effects of drying temperature and ethanol concentration on bipolar switching characteristics of natural Aloe vera-based memory devices. Phys Chem Chem Phys2015; 17: 26833–26853.
34.
BuraidahMHArofAK. Characterization of chitosan/PVA blended electrolyte doped with NH4I. J Non-Cryst Solids2011; 357: 3261–3266.
35.
Abd-ElghanyAAMohamadEA. Antitumor impact of iron oxide nanoparticles in Ehrlich carcinoma-bearing mice. J Radiat Res Appl Sci2021; 14(1): 314–321.
MozafariMR. In nanomaterials and nanosystems for biomedical applications. Springer, 2007.
38.
StohrEBhandarePPeuraRA, et al. IR spectrophotometric measurement of glucose in phosphate buffered saline solutions: effects of temperature and pH,” [1992] Proceedings of the Eighteenth IEEE Annual Northeast Bioengineering Conference, 1992, pp. 103–104, doi: 10.1109/NEBC.1992.285973
39.
TarekegnAJosephNMPalaniS, et al. Niosomes in targeted drug delivery: some recent advances. IJPSR2010; 1(9): 1–8.
40.
AbdelkaderHFarghalyUMoharramH. Effects of surfactant type and cholesterol level on niosomes physical properties and in vivo ocular performance using timolol maleate as a model drug. J Pharm Investig2014; 44: 329–337.
41.
KaurAThataiPSapraB. Need of UV protection and evaluation of efficacy of sunscreens. J Cosmet Sci2014; 65(5): 315–345.
