Digital light procession three-dimensional printing acrylate/collagen composite airway stent for tracheomalacia

Abstract

Recently, more and more researchers have focused on airway stent applied in tracheomalacia. The airway stents for clinical application were usually manufactured in accordance with a fixed pattern, which were difficult to perfect match with children, especially infants. Digital light procession of light curing acrylate resin implantation showed higher accuracy and printing speed over traditional three-dimensional printing techniques. In this article, a novel personalized airway stent was developed by digital light procession three-dimensional printing and was modified by collagen I extracted from the fish scales. The morphology of the collagen-modified airway stent was examined by scanning electron microscopy, and the chemical structures were examined by attenuated total internal reflectance Fourier transform infrared spectroscopy. The biocompatibility of this synthetic acrylate/collagen composite airway stent was characterized by water contact angle test and cell culture. The results confirmed that the composite airway stent was hydrophilic and non-cytotoxic toward a cultured human bronchial epithelial cell line with good cell viability and show excellent physicochemical and biological properties. In conclusion, this study presented the three-dimensional printing composite acrylate and collagen airway stent may have potential in customized treatment for tracheomalacia.