Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of polymer scaffolds such as poor compressive strength and bioactivity. In this study, poly(vinyl alcohol)/calcium silicate (CaSiO3) composite scaffolds with fully interconnected porous structures and customized shapes were successfully fabricated via selective laser sintering. The microstructure, porosity, and mechanical properties of the scaffolds were characterized. Based on the results, CaSiO3 particles were well dispersed and embedded in the poly(vinyl alcohol) matrix after sintering. The compressive strength increased with increasing the content of CaSiO3 up to 15 wt%, and then decreased with further increasing CaSiO3 content to 20 wt%. Our study also revealed that the scaffolds could not be fabricated successfully as fewer poly(vinyl alcohol) particles fused together when CaSiO3 was higher than 20 wt%. Based on the in vitro data, the poly(vinyl alcohol)/CaSiO3 composite scaffolds possess good bioactivity and cytocompatibility.
KyriakidouKLucariniGZizziA. Dynamic co-seeding of osteoblast and endothelial cells on 3D polycaprolactone scaffolds for enhanced bone tissue engineering. J Bioact Compat Polym2008; 23: 227–243.
2.
PengLChengXRWangJW. Preparation and evaluation of porous chitosan/collagen scaffolds for periodontal tissue engineering. J Bioact Compat Polym2006; 21: 207–220.
3.
PuppiDPirasAMDettaN. Poly(vinyl alcohol)-based electrospun meshes as potential candidate scaffolds in regenerative medicine. J Bioact Compat Polym2011; (26): 20–34.
4.
SaitoEKangHTaboasJM. Experimental and computational characterization of designed and fabricated 50:50 PLGA porous scaffolds for human trabecular bone applications. J Mater Sci Mater Med2010; 21(8): 2371–2383.
5.
ShaoCKimHYGongJ. Fiber mats of poly(vinyl alcohol)/silica composite via electrospinning. Mater Lett2003; 57: 1579–1584.
6.
KrumovaMLópezDBenaventeR. Effect of crosslinking on the mechanical and thermal properties of poly(vinyl alcohol). Polymer2000; 41: 9265–9272.
7.
ShuaiCMaoZLuH. Fabrication of porous poly(vinyl alcohol) scaffold for bone tissue engineering via selective laser sintering. Biofabrication2013; 5: 015014 (8 pp.).
8.
ShuaiCJMaoZZGaoCD. Development of complex porous poly(vinyl alcohol) scaffolds: microstructure, mechanical, and biological evaluations. J Mech Med Biol2013; 13: 1350034 (12 pp.).
9.
SiriphannonPKameshimaYYasumoriA. Influence of preparation conditions on the microstructure and bioactivity of a-CaSiO3 ceramics: formation of hydroxyapatite in simulated body fluid. J Biomed Mater Res2000; 52: 30–39.
10.
KimSSParkMSJeonO. Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. Biomaterials2006; 27: 1399–1409.
MaPXZhangR. Microtubular architecture of biodegradable polymer scaffolds. J Biomed Mater Res2001; 56: 469–477.
13.
ThomsonRCYaszemskiMJPowersJM. Hydroxyapatite fiber reinforced poly(alpha-hydroxy ester) foams for bone regeneration. Biomaterials1998; 12: 1935–1943.
14.
AhoAJTirriTKukkonenJ. Injectable bioactive glass/biodegradable polymer composite for bone and cartilage reconstruction: concept and experimental outcome with thermoplastic composites of poly(epsilon-caprolactone-co-d,l-lactide) and bioactive glass S53P4. J Mater Sci Mater Med2004; 15: 1165–1173.
15.
LuHHEl-AminSFScottKD. Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro. J Biomed Mater Res A2003; 64: 465–474.
16.
KalitaSJBoseSHosickHL. Development of controlled porosity polymer-ceramic composite scaffolds via fused deposition modeling. Mat Sci Eng: C2003; 23: 611–620.
17.
LiaoHTChangKHJiangY. Fabrication of tissue engineered PCL scaffold by selective laser-sintered machine for osteogeneisis of adipose-derived stem cells. Virtual Phys Prototyp2011; 6: 57–60.
18.
HoqueMEChuanYLPashbyI. Extrusion based rapid prototyping technique: an advanced platform for tissue engineering scaffold fabrication. Biopolymers2012; 97: 83–93.
19.
ZhouWYWangMCheungWL. Selective laser sintering of poly(l-lactide)/carbonated hydroxyapatite nanocomposite porous scaffolds for bone tissue engineering. Tissue Eng2010; 9: 180–202.
20.
WiriaFELeongKFChuaCK. Poly-ε-caprolactone/hydroxyapatite for tissue engineering scaffold fabrication via selective laser sintering. Acta Biomater2007; 3: 1–12.
21.
KokuboTTakadamaH. How useful is SBF in predicting in vivo bone bioactivity?Biomaterials2006; 27: 2907–2915.
22.
WilmonskyVLutzCRMeiselU. In vivo evaluation of ß-TCP containing 3D laser sintered poly(ether ether ketone) composites in pigs. J Bioact Compat Polym2009; 24: 169–184.
23.
MaXWangYGuoH. Nano-hydroxyapatite/chitosan sponge-like biocomposite for repairing of rat calvarial critical-sized bone defect. J Bioact Compat Polym2011; 26: 335–346.
24.
ShuaiCJGaoCDNieY. Structure and properties of nano-hydroxyapatite scaffolds for bone tissue engineering with selective laser sintering system. Nanotechnol2011; 22: 285703 (9 pp.).
25.
ChuaCKLeongKFTanKH. Development of tissue scaffolds using selectivelaser sintering of poly(vinyl alcohol)/hydro-xyapatite biocomposite for craniofacial and joint defects. J Mater Sci Mater Med2004; 15: 1113–1121.
26.
LongLZhangFChenL. Preparation and properties of β-CaSiO3/ZrO2 (3Y) nanocomposites. J Eur Ceram Soc2008; 28: 2883–2887.
