Abstract
Dendritic poly-[N-(2-hydroxyethyl)-L-glutamine] (PHEG) with different molecular weights were synthesized by aminolysis of dendritic poly-(γ-benzyl-L-glutamate) (PBG), which was obtained by polymerization of the corresponding N-carboxyanhydride (NCA) with poly(amido amine) (PAMAM, starburst®) of the fourth generation as initiator. Dynamic light scattering (DLS) was used to determine the size of the polymeric carriers and to compare the dendritic polymer to the linear analogue. The body distribution and blood clearance of 125 I-radiolabelled linear and dendritic PHEG with similar molecular weight were investigated in female BALB/c mice.
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References
1.
1.
Putnam, D.
and
Kopecek, J.
(1995 ). Adv. Polymer. Sci. , 122 : 55 -55 .
2.
2.
Duncan, R.
(1992 ). Anti-Cancer Drugs , 3 : 175 -175 .
3.
3.
Monfardini, C.
and
Veronese, F.M.
(1998 ). Bioconjugate Chem. , 9 : 418 -418 .
4.
4.
Duncan, R.
(2003 ). Nature Reviews Drug Discovery , 2 : 347 -347 .
5.
5.
Seymour, L.W.
,
Duncan, R.
,
Kopeckova, P.
and
Kopecek, J.
(1987 ). Cancer Treat. Rev. , 14 : 319 -319 .
6.
6.
Rihova, B.
,
Veres, K.
,
Fornusek, L.
,
Ulbrich, K.
,
Strohalm, J.
,
Vetvicka, V.
,
Bilej, M.
and
Kopecek J.
(1989 ). J. Control. Rel ., 10 : 37 -37 .
7.
7.
Soyez, H.
,
Schacht, E.
,
Jelinkova, M.
and
Rihova, B.
(1997 ). J. Control. Rel. , 47 : 71 -71 .
8.
8.
Matsumura, Y.
and
Maeda H.
(1986 ). Cancer Res ., 46 : 6387 -6387 .
9.
9.
Maeda, H.
,
Matsumura, Y.
and
Kato, H.
(1988 ). J. Biol. Chem ., 263 : 16051 -16051 .
10.
10.
Seymour, L.W.
(1992 ). Crit. Rev. Ther. Drug Carrier Syst ., 9 : 135 -135 .
11.
11.
Maeda, H.
,
Seymour, L.
and
Miyamoto, Y.
(1992 ). Bioconjugate Chem ., 3 : 351 -351 .
12.
12.
Maeda, H.
(1991 ). Adv. Drug Delivery Rev. , 6 : 181 -181 .
13.
13.
Maeda, H.
,
Sawa, T.
and
Konno, T.
(2001 ). J. Control. Release ., 74 : 47 -47 .
14.
14.
Maeda, H.
(2001 ). Adv. Drug Del. Rev ., 46 : 169 -169 .
15.
15.
Duncan, R.
,
Seymour, L.W.
,
Scarlett, L.
,
Lloyd, J.B.
,
Rejmanova, P.
and
Kopecek, J.
(1986 ). J. Biochem. Biophys. Acta , 886 : 62 -62 .
16.
16.
Vansteenkiste, S.
,
Schacht, E.
,
Seymour, L.
and
Duncan, R.
(1993 ). In:
El-Nokaly, M.
,
Piatt, D.
and
Charpentier, B.
(eds) Polymer Delivery Systems . ACS Sym. Ser. , 520: 362 -362 .
17.
17.
Seymour, L.W.
,
Flanagan, P.A.
,
Alshamkhani, A.
,
Subr V.
,
Ulbrich, K.
,
Cassidy, J.
and
Duncan, R.
(1991 ). Select Cancer Ther. , 7 : 59 -59 .
18.
18.
Seymour, L.W.
,
Ferry, D.R.
,
Anderson, D.
,
Hesslewood, S.
,
Julyan, P.J.
,
Poyner, R.
,
Doran, J.
,
Young, A.M.
,
Burtles, S.
and
Kerr, D.J.
(2002 ). J. Clin. Oncol. , 20 : 1668 -1668 .
19.
19.
De Duve, C.
,
De Barsy, T.
,
Poole, B.
,
Trouet, A.
,
Tulkens, P.
and
Van Hoof, F.
(1974 ). Biochem. Pharmacol. , 23 : 2495 -2495 .
20.
20.
Minko, T.
,
Kopeckova, P.
,
Pozharov, V.
and
Kopecek, J.
(1998 ). J. Control. Rel. , 54 : 223 -223 .
21.
21.
Neri, P.
,
Antoni, A.
,
Benvenuti, F.
,
Cocola, F.
and
Gazzei, G.
(1973 ). J. Med. Chem ., 16 : 893 -893 .
22.
22.
Gerda, A.
,
Antoni, G.
,
Benvenuti, F.
,
Cocola, F.
and
Neri, P.
(1970 ). Adv. Exp. Med. Biol ., 9 : 329 -329 .
23.
23.
Pytela, J.
,
Saudek, V.
,
Drobnik J.
and
Rypacek, F.
(1989 ). J. Control. Release , 10 : 17 -17 .
24.
24.
Pytela, J.
,
Kotva, R.
,
Metalova, M.
and
Rypacek, F.
(1990 ). Int. J. Biol. Macromol ., 12 : 241 -241 .
25.
25.
Pytela, J.
,
Jakes, J.
and
Rypacek, F.
(1994 ). Int. J. Biol. Macromol ., 16 (1 ): 15 -15 .
26.
26.
Pytela, J.
,
Kotva, R.
and
Rypacek, F.
(1998 ). J. Bioact. Compat. Polymers , 13 (3 ): 198 -198 .
27.
27. Soyez, H. (1997). PhD thesis, Ghent University.
28.
28.
De Marre, A.
,
Soyez, H.
and
Schacht, E.
(1992 ). Makromol. Chem. , 193 : 3023 -3023 .
29.
29.
Liu, M.
and
Fréchet, M.J.
(1999 ). Pharm. Sci. Technol. Today , 2 (10 ): 393 -393 .
30.
30.
Liu, M.
,
Kono, K.
and
Fréchet, J.M.J.
(1999 ). J. Polymer Sci.: Part A: Polymer Chem. , 37 : 3492 -3492 .
31.
31.
Haensler, J.
and
Szoka F.C.
(1993 ). Bioconjugate Chem ., 4 : 372 -372 .
32.
32.
Malik, N.
,
Evagorou, E.G.
and
Duncan, R.
(1999 ). Anti-Cancer Drugs , 10 (8 ): 767 -767 .
33.
33.
Malik, N.
,
Wiwattanapatapee, R.
,
Klopsch, R.
,
Lorenz, K.
,
Frey, H.
,
Weener, J.W.
,
Meijer, E.W.
,
Paulus, W.
and
Duncan, R.
(2000 ). J. Control. Release , 65 : 133 -133 .
34.
34.
Wiener, E.C.
,
Konda, S.
,
Shadron, A.
,
Brechbiel, M.
and
Gansow, O.
(1997 ). Invest. Radiol ., 32 : 748 -748 .
35.
35.
Schwickert, H.C.
,
Roberts, T.P.L.
,
Muhler, A.
,
Stwaskal, M.
,
Demsar, F.
and
Brasch, R.C.
(1995 ). Eur. J. Radiol ., 20 : 144 -144 .
36.
36.
Jansen, J.F.G.A.
,
Meijer, E.W.
and
de Brabander-van den Berg, E.M.M.
(1994 ). Science , 266 : 1226 -1226 .
37.
37.
Singh, P.
,
Moll, F.
,
Lin, S.H.
,
Ferzli, C.
,
Yu, K.S.
,
Koski, R.K.
,
Saul, R.G.
and
Cronin, P.
(1994 ). Clin. Chem. , 40 (9 ): 1845 -1845 .
38.
38.
Mitchell, J.P.
,
Roberts, K.D.
,
Langley, J.
,
Koentgen, F.
and
Lambert, J.N.
(1999 ). Bioorg. Med. Chem. Lett. , 9 : 2785 -2785 .
39.
39.
Andre, S.
,
Ortega, P.J.C.
,
Perez, M.A.
,
Roy, R.
and
Gabius, H.J.
(1999 ). Glycobiology , 9 (11 ): 1253 -1253 .
40.
40.
Aoi, K.
,
Tsutsumiuchi,K.
,
Aoki, E.
and
Okada, M.
(1996 ). Macromolecules , 29 : 4456 -4456 .
41.
41.
Dimitrijevic, S.
and
Duncan, R.
(1998 ). J. Bioact. Compat. Pol. , 13 : 165 -165 .
42.
42.
Ulbrich, K.
,
Pechar, M.
,
Strohalm, J.
and
Subr, V.
(1997 ). Macromol. Symp. , 118 : 577 -577 .
43.
43.
Oupicky, D.
,
Ulbrich, K.
and
Rihova, B.
(1999 ). J. Bioact. Compat. Pol. , 14 : 213 -213 .
44.
44.
Wang, D.
,
Kopeckova, P.
,
Minko, T.
,
Nanyakkara, V.
and
Kopecek, J.
(2000 ). Polymer Preprints , 41 (1 ): 994 -994 .
45.
45.
Wang, D.
,
Kopeckova, P.
,
Minko, T.
,
Nanayakkara, V.
,
Kopecek, J.
(2000 ). Biomacromol ., 1 : 313 -313 .
46.
46.
Choi, W.M.
,
Kopeckova, P.
,
Minko, T.
,
Kopecek, J.
(1999 ). J. Bioact. Compat. Pol. , 14 : 447 -447 .
47.
47.
Guttmannn, S.
and
Boissonnas, R.
(1958 ). Helv. Chim. Act , 41 : 1852 -1852 .
48.
48.
De Marre, A.
,
Soyez, H.
,
Schacht, E.
and
Pytela, J.
(1994 ). Polymer , 35 (11 ): 2443 -2443 .
49.
49.
Vanderkerken, S.
,
De Winne, K.
,
Toncheva, V.
and
Schacht, E.
Makromolekulare Chemie, Rapid Communications , submitted for publication.
50.
50.
Tomalia, D.A.
,
Baker, H.
,
Dewald, J.
,
Hall, M.
,
Kallos, G.
,
Martin, S.
,
Roeck, J.
,
Ryder, J.
and
Smith, P.
(1985 ). Polymer J. , 17 : 117 -117 .
51.
51.
Tomalia, D.A.
,
Naylor, A.M.
and
Goddard, W.A.
(1990 ). Angew. Chem. Int. Ed. Eng. , 29 : 138 -138 .
52.
52.
Ashton, P.R.
,
Hounsell, E.F.
,
Jayaraman, N.
,
Nilsen, T.M.
,
Spencer, N.
,
Stoddart, J.F.
and
Young, M.
(1998 ): J. Org. Chem ., 63 (10 ): 3429 -3429 .
53.
53.
Malik, N.
,
Wiwattanapatapee, R.
,
Klopsch, R.
,
Lorenz, K.
,
Frey, H.
,
Weener, J.W.
,
Meijer, E.W.
,
Paulus, W.
and
Duncan, R.
(2000 ). J. Control. Release , 65 : 133 -133 .
54.
54. Hoste, K. (1999). PhD thesis, University Ghent.
55.
55.
Schacht, E.H.
,
Hoste, K.
(1997 ). In: Poly(ethylene glycol) : Chemistry and Biological Applications ,
Harris, J.M.
and
Zalipsky, S.
(eds), Washington, DC , ACS , p. 297 -297 .