This article aims to describe a rare cause of severe encephalitis in 2 cases of infants with signs of intracranial hypertension and severe autonomic dysregulation. The authors conclude that human parechoviruses are becoming a more recognized cause of encephalitis because of the increasing use of rapid detection methods. With early recognition of this clinical entity, improved care can be administered.
KhatamiAMcMullanBJWebberM. Sepsis-like disease in infants due to human parechovirus type 3 during an outbreak in Australia. Clin Infect Dis. 2015;60(2):228–236.
3.
Verboon-MaciolekMAKredietTGGerardsLJ. Severe neonatal parechovirus infection and similarity with enterovirus infection. Pediatr Infect Dis J. 2008;27(3):241–245.
4.
ItoMYamashitaTTsuzukiH. Isolation and identification of a novel human parechovirus. J Gen Virol. 2004;85(pt 2):391–398.
5.
YuzuriharaSSAoKHaraT. Human parechovirus-3 infection in nine neonates and infants presenting symptoms of hemophagocytic lymphohistiocytosis. J Infect Chemother. 2013;19(1):144–148.
6.
NireiJAizawaMKobayashiA. Human parechovirus type 3 infection: cause of apnea in infants born prematurely. Pediatr Int. 2016;58(5):400–402.
7.
BrittonPNDaleRCNissenMD. Parechovirus encephalitis and neurodevelopmental outcomes. Pediatrics. 2016;137(2):e20152848.
8.
WolthersKCBenschopKSSchinkelJ. Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children. Clin Infect Dis. 2008;47(3):358–363.
9.
RenaudCHarrisonCJ. Human parechovirus 3: the most common viral cause of meningoencephalitis in young infants. Infect Dis Clin North Am. 2015;29(3):415–428.
10.
VolpeJJ. Neonatal encephalitis and white matter injury: more than just inflammation. Ann Neurol. 2008;64(3):232–236.
11.
WatanabeTTakahashiMShojiK. Human parechovirus-3 infection mimicking Hirschsprung-associated enterocolitis. J Pediatr Surg Case Rep. 2014;2(2):58–60.
12.
BrownellADReynoldsTQLivingstonB. Human parechovirus-3 encephalitis in two neonates: acute and follow-up magnetic resonance imaging and evaluation of central nervous system markers of inflammation. Pediatr Neurol. 2015;52(2):245–249.
13.
WatanabeKHayakawaFOkumuraA. Neonatal EEG: a powerful tool in the assessment of brain damage in preterm infants. Brain Dev. 1999;21(6):361–372.
