The authors present a case of diffuse intrinsic pontine glioma presenting in a newborn with stridor and respiratory distress that progressed to respiratory failure. Magnetic resonance imaging (MRI) of the brain revealed findings compatible with the diagnosis of diffuse intrinsic pontine glioma. The family pursued palliative care and postmortem examination confirmed WHO grade III astrocytoma.
JalloGIBiser-RohrbaughAFreedD. Brainstem gliomas. Childs Nerv Syst. 2004;20:143–153.
2.
FisherPGBreiterSNCarsonBS. A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. Cancer. 2000;89:1569–1576.
3.
SchomerusLMerkenschlagerAKahnTHirschW. Spontaneous remission of a diffuse brainstem lesion in a neonate. Pediatr Radiol. 2007;37:399–402.
4.
ThompsonWDKosnikEJ. Spontaneous regression of a diffuse brainstem lesion in the neonate. J Neurosurg Pediatr. 2005;102:65–71.
BuczkowiczPHoemanCRakopoulosP. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet. 2014;46:451–456.
14.
Morales La MadridAHashizumeRKieranMW. Future clinical trials in DIPG: bringing epigenetics to the clinic. Front Oncol. 2015;5:1–5.
15.
WarrenKE. Diffuse intrinsic pontine glioma: poised for progress. Front Oncol. 2012;2:1–9.
16.
SchroederKMHoemanCMBecherOJ. Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology. Pediatr Res. 2014;75:205–209.
