The ketogenic diet is not a new treatment for the treatment of epilepsy, but the degree of literature now available seems to have given it a new lease of life. Over the past 12 years, there has been more scientific data on both benefits and effect of the ketogenic diet. Data demonstrate a clear benefit in efficacy. We also have a clearer idea in utilization, type of diet to use, and in whom. Questions however remain and further work is required, not least in recognizing likely candidates and in simplifying administration.
KeeneDL. A systematic review of the use of the ketogenic diet in childhood epilepsy. Pediatr Neurol. 2006;35:1–5.
2.
HendersonCBFillouxFMAlderSCLyonJLCaplinDA. Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J Child Neurol. 2006;21:193–198.
3.
LefevreFAronsonN. Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy. Pediatrics. 2000;105:e46.
4.
LevyRGCooperPNGiriP.Ketogenic diet and other dietary treatments for epilepsy (review). Cochrane Database Syst Rev. 2012;(3):CD001903.
5.
NealEGChaffeHMSchwartzRH. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008;7:500–506.
6.
NealEGChaffeHMSchwartzRH. A randomised controlled trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia. 2009;50:1109–1117.
7.
SeoJHLeeYMLeeJSKangHCKimHC. Efficacy and tolerability o the ketogenic diet according to lipid: nonlipid ratios—comparison of 3:1 with 4:1 diet. Epilepsia. 2007;48:801–805.
8.
BergqvistAGCSchallJIGallagherPRCnaanAStallingsVA. Fasting vs gradual initiation of the ketogenic diet: a prospetive randomised clinical trial of efficacy. Epilepsia. 2005;46:1810–1819.
9.
KossoffEHTurnerZBlumlRMPyzikPLViningEPG. A randomized crossover comparison of daily carbohydrate limits using the modified Atkins diet. Epilepsy Behav. 2007;10:432–436.
10.
ViningEPGKossoffEHPyzikPLYeXGoodmanSN. A blinded, crossover study of the efficacy of the ketogenic diet. Epilepsia. 2009;50:322–325.
11.
SharmaSSankhyanNGulatiSAgarwalaA. Use of the modified Atkins diet for treatment of refractory childhood epilepsy: a randomised controlled trial. Epilepsia. 2013;54:481–486.
12.
BergATBerkovicSFBrodieMJ. Revised terminology and concepts for organisation of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51:676–685.
13.
KossoffEHHedderickEFTurnerZFreemanJM. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia. 2008;49:1504–1509.
14.
NumisALYellenMBChu-ShoreCJPfeiferHHThieleEA. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Res. 2011;96:172–175.
15.
HongAMTurnerZHamdyRFKossoffEH. Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants. Epilepsia. 2010;51:1403–1407.
16.
KangHCLeeYJLeeJS. Comparison of short-versus long-term ketogenic diet for intractable infantile spasms. Epilepsia. 2011;52:781–787.
17.
FerlazzoENikaronovaMItalianoD. Lennox-Gastaut syndrome in adulthood: clinical and EEG features. Epilepsy Res. 2010;89:271–277.
18.
LemmonMETeraoNNNgY-TReisigWRubensteinJEKossoffEH. Efficacy of the ketogenic diet in Lennox-Gastaut syndrome: a retrospective review of one institution's experience and summary of the literature. Dev Med Child Neurol. 2012;54:464–468.
19.
CaraballoRHCersosimoROSakrDCrestaAEscobalNFejermanN. Ketogenic diet in patients with Dravet syndrome. Epilepsia. 2005;46:1539–1544.
20.
NabboutRCopioliCChipauxM. Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: a prospective pilot study. Epilepsia. 2011;52:e54–e57.
21.
OguniHTanakaTHayashiK. Treatment and long term prognosis of myoclonic astatic epilepsy of early childhood. Neuropediatrics. 2002;33:122–132.
22.
SulsAMullenSAWeberYG. Early onset absence epilepsy caused by mutations in the glucose transporter GLUT1. Ann Neurol. 2009;66:415–419.
23.
MullenSAMariniCSulsA. Glucose transporter 1 deficiency as a treatable cause of myoclonic astatic epilepsy. Arch Neurol. 2011;68:1152–1155.
24.
ArsovTMullenSARogersS. Glucose transporter 1 deficiency in the idiopathic generalized epilepsies. Ann Neurol. 2012;72:807–815.
25.
ThammongolSVearsDFBicknell-RoyleJ. Efficacy of the ketogenic diet: which epilepsies respond?Epilepsia. 2012;53:e55–e59.
26.
JungDEKangHCKimHD. Long-term outcome of the ketogenic diet for intractable childhood epilepsy with focal cortical malformation of cortical development. Pediatrics. 2008;122:e330–e333.
27.
NamSHLeeBLLeeCG. The role of ketogenic diet in the treatment of refractory status epilepticus. Epilepsia. 2011;52:e181–e184.
28.
NabboutRMazzucaMHubertP. Efficacy of the ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia. 2010;51:2033–2037.
29.
KramerUChiCSLinKL. Febrile infection-related epilepsy syndrome (FIRES): pathogenesis, treatment, and outcome. A multicentre study on 77 children. Epilepsia. 2011;52:1956–1965.
30.
VilleneuveNPintonFBahi-BuissonNDulacOChironCNabboutR. The ketogenic diet improves recently worsened focal epilepsy. Dev Med Child Neurol. 2009;51:276–281.
31.
MosekANatourHNeufledMYShiffYVaismanN. Ketogenic diet treatment in adults with refractory epilepsy: a prospective study. Seizure. 2009;18:30–33.
32.
KossoffEHRowleyHSinhaSRViningEPG. A prospective study of the modified Atkins diet for intractable epilepsy in adults. Epilepsia. 2008;49:316–319.
33.
MuzykewiczDALyczkowskiDAMemonNConantKDPfeiferHHThieleEA. Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy. Epilepsia. 2009;50:1118–1126.
34.
KlepperJLeiendeckerB. GLUT1 deficiency syndrome—2007 update. Dev Med Child Neurol. 2007;49:707–716.
35.
KossoffEHCaraballoRHdu ToitT. Dietary therapies: a worldwide phenomenon. Epilepsy Res. 2012;100:205–209.
36.
National Institute of Health and Clinical Excellence. Diagnosis and management of the epilepsies in adults and children in primary and secondary care. 2012. www.nice.org.uk/cg137.
37.
PellockJMHrachovyRAShinnarS. Infantile spasms: a U.S. consensus report. Epilepsia. 2010;51:2175–2189.
