Septal Perforation Repair Without Intraoperative Mucosal Closure in a Patient With Graft Versus Host Disease

Abstract

We report a technique used to achieve successful repair of 2 large septal perforations in a patient with graft versus host disease, chronic use of corticosteroids, and chronic use of immunosuppressive medications. A multilayered interposition graft was constructed out of temporal fascia and flexible polydioxanone plates and placed between the mucoperichondrial flaps. Due to large size of the perforations and poor tissue quality, no attempt at mucosal closure of the perforations was made. Instead, silicone sheets were placed for 52 days to facilitate healing. Complete healing of both perforations sites was obtained along with resolution of the patient’s symptoms. The described technique provided an optimal surgical outcome in the setting of multiple large septal perforations, graft versus host disease, chronic corticosteroids, and chronic immunosuppressive medications.