Dioxin-like compounds, recognized by the World Health Organization (WHO) as among the most enduring toxic chemical substances in the environment, are linked to various occupational activities and industrial accidents worldwide. The aim of this study was to examine and present research publications on dioxins, pinpoint current research trends, identify research gaps, and highlight potential avenues for future exploration in the field. The study period for relevant research articles ranged from 1923 to December 31, 2022, and these articles were sourced from the Scopus database. The analysis involved the identification of key contributors to the field and the visualization of topics, themes, and international collaboration. VOSviewer software (version 1.6.20) was used for visualization analysis. A total of 11,620 publications on dioxins were documented in the Scopus database. The predominant category of these documents comprised 9780 original articles, which represents 84.17% of the total publications. The United States lead in the number of publications, with 3992 (34.35%), followed by Japan, with 1429 (12.3%), China, with 1005 (8.65%), and Germany, with 974 (8.38%). Before 2002, scholarly attention in this field focused primarily on the health effects, environmental fate, and mechanism of toxicity of tetrachlorodibenzo-p-dioxin (TCDD). However, a noticeable change in research focus has been observed since 2002, highlighting the emergence of a topic related to the health effects and environmental fate of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PFDFs). This study is the first to conduct a comprehensive quantitative bibliometric analysis of dioxins over time. These findings indicate a significant increase in the overall growth of the dioxin literature over the past 30 years. These findings may prove crucial in guiding and organizing subsequent investigations related to dioxins.
Al-JabiSW (2017) Global trends in aspirin resistance-related research from 1990 to 2015: a bibliometric analysis. Basic and Clinical Pharmacology and Toxicology121(6): 512–519.
2.
Al-JabiSW (2021) Current global research landscape on COVID-19 and depressive disorders: bibliometric and visualization analysis. World Journal of Psychiatry11(6): 253–264.
3.
AleixandreJLAleixandre-TudóJLBolaños-PizarroM, et al. (2015) Mapping the scientific research in organic farming: a bibliometric review. Scientometrics105(1): 295–309.
4.
AlRyalatSASMalkawiLWMomaniSM (2019) Comparing bibliometric analysis using PubMed, Scopus, and web of science databases. Journal of Visualized Experiments: JoVE(152): e58494. DOI: 10.3791/58494.
5.
AnkerMSHadzibegovicSLenaA, et al. (2019) The difference in referencing in web of science, Scopus, and google scholar. ESC Heart Failure6(6): 1291–1312.
6.
ApukeODIyendoTO (2018) University students’ usage of the internet resources for research and learning: forms of access and perceptions of utility. Heliyon4(12): e01052.
7.
ArisawaK (2018) Recent decreasing trends of exposure to PCDDs/PCDFs/dioxin-like PCBs in general populations, and associations with diabetes, metabolic syndrome, and gout/hyperuricemia. Journal of Medical Investigation: JMI65(3.4): 151–161.
8.
ArisawaKTakedaHMikasaH (2005) Background exposure to PCDDs/PCDFs/PCBs and its potential health effects: a review of epidemiologic studies. Journal of Medical Investigation: JMI52(1-2): 10–21.
9.
ArmitageJMGinevanMEHewittA, et al. (2015) Environmental fate and dietary exposures of humans to TCDD as a result of the spraying of Agent Orange in upland forests of Vietnam. The Science of the Total Environment506-507: 621–630.
10.
BacaDMonroyRCastilloM, et al. (2023) Dioxins and plastic waste: a scientometric analysis and systematic literature review of the detection methods. Environmental Advances13: 100439.
11.
BakkalbasiNBauerKGloverJ, et al. (2006) Three options for citation tracking: google scholar, Scopus and web of science. Biomedical Digital Libraries3: 7.
12.
BansalRMartinhoCPruthiN, et al. (2024) From virtual observations to business insights: a bibliometric review of netnography in business research. Heliyon10(1): e22853.
13.
BertazziPAConsonniDBachettiS, et al. (2001) Health effects of dioxin exposure: a 20-year mortality study. American Journal of Epidemiology153(11): 1031–1044.
14.
BondC (2023) Revisiting publish or perish. International Journal of Pharmacy Practice31(1): 1–2.
15.
BordonsMFernándezMTGómezI (2002) Advantages and limitations in the use of impact factor measures for the assessment of research performance. Scientometrics53(2): 195–206.
16.
BravemanPGottliebL (2014) The social determinants of health: it's time to consider the causes of the causes. Public Health Reports129(Suppl 2): 19-31.
17.
Bruner-TranKLGneccoJDingT, et al. (2017) Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: translating lessons from murine models. Reproductive Toxicology68: 59–71.
18.
CoboMJLópez-HerreraAGHerrera-ViedmaE, et al. (2011) Science mapping software tools: review, analysis, and cooperative study among tools. Journal of the American Society for Information Science and Technology62(7): 1382–1402.
19.
ColePTrichopoulosDPastidesH, et al. (2003) Dioxin and cancer: a critical review. Regulatory Toxicology and Pharmacology: Regulatory Toxicology and Pharmacology38(3): 378–388.
20.
CostasRBordonsM (2007) The h-index: advantages, limitations and its relation with other bibliometric indicators at the micro level. Journal of Informetrics1(3): 193–203.
21.
de SouzaHFMonteiroGFBogazLT, et al. (2024) Bibliometric analysis of water kefir and milk kefir in probiotic foods from 2013 to 2022: a critical review of recent applications and prospects. Food Research International175: 113716.
22.
DomingoJLGarciaFNadalM, et al. (2017) Autopsy tissues as biological monitors of human exposure to environmental pollutants. A case study: concentrations of metals and PCDD/Fs in subjects living near a hazardous waste incinerator. Environmental Research154: 269–274.
23.
DopicoMGómezA (2015) Review of the current state and main sources of dioxins around the world. Journal of the Air & Waste Management Association (1995)65(9): 1033–1049.
24.
EdejerTT (2000) Disseminating health information in developing countries: the role of the internet. BMJ321(7264): 797–800.
25.
EFSA Panel on Contaminants in the Food Chain CONTAMKnutsenHKAlexanderJBarregårdL, et al. (2018) Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food. EFSA journal. European Food Safety Authority16(11): e05333.
26.
ErmawanRCorriganHWiyonoN (2024) Current update and trend of 3D printing in spinal surgery: a bibliometric analysis and review of literature. Journal of Orthopaedics50: 22–28.
27.
EsserC (2014) Dioxins and the immune system. In: VohrH-W (ed) Encyclopedia of Immunotoxicology. Berlin, Heidelberg: Springer, 1–7.
28.
FaimanB (2021) Publish or perish. Journal of the Advanced Practitioner in Oncology12(5): 463–464.
29.
FalagasMEPitsouniEIMalietzisGA, et al. (2008) Comparison of PubMed, Scopus, web of science, and google scholar: strengths and weaknesses. The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology22(2): 338–342.
30.
FanZCaseyFXLarsenGL, et al. (2006) Fate and transport of 1278-TCDD, 1378-TCDD, and 1478-TCDD in soil-water systems. The Science of the Total Environment371(1–3): 323–333.
31.
FeeleyMBrouwerA (2000) Health risks to infants from exposure to PCBs, PCDDs and PCDFs. Food Additives & Contaminants17(4): 325–333.
32.
Fernandez-SalgueroPPineauTHilbertDM, et al. (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science268(5211): 722–726.
33.
FigueiraIda LuzMBragaRJ, et al. (2007) The increasing internationalization of mainstream posttraumatic stress disorder research: a bibliometric study. Journal of Traumatic Stress20(1): 89–95.
34.
FingerhutMAHalperinWEMarlowDA, et al. (1991) Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. New England Journal of Medicine324(4): 212–218.
35.
FontanarosaPBDeAngelisCDHuntN (2005) Medical research--state of the science. JAMA, the Journal of the American Medical Association294(11): 1424–1425.
36.
GonzalezNMarquesMNadalM, et al. (2018) Levels of PCDD/Fs in foodstuffs in Tarragona County (Catalonia, Spain): spectacular decrease in the dietary intake of PCDD/Fs in the last 20 years. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association121: 109–114.
37.
GreimH (2023) Dioxins. Encyclopedia of Toxicology: V3–851. 4th edition, 1–9.
38.
GuoJBoXXieY, et al. (2023) Health effects of future dioxins emission mitigation from Chinese municipal solid waste incinerators. Journal of Environmental Management345: 118805.
39.
GüvenECGedikK (2016) Global research activities on dioxins and dioxin-like compounds. International Journal of Environment and Pollution60(1/2/3/4): 12–33.
40.
HallAMattisonDSinghN, et al. (2023) Effect of TCDD exposure in adult female and male mice on the expression of miRNA in the ovaries and testes and associated reproductive functions. Frontiers in Toxicology5: 1268293.
41.
HarzingA-WAlakangasS (2015) Google scholar, Scopus and the web of science: a longitudinal and cross-disciplinary comparison. Scientometrics106(2): 787–804.
42.
HawsLCSuSHHarrisM, et al. (2006) Development of a refined database of mammalian relative potency estimates for dioxin-like compounds. Toxicological Sciences: An Official Journal of the Society of Toxicology89(1): 4–30.
43.
HengKHamidMKhanA (2020) Factors influencing academics' research engagement and productivity: a developing countries perspective. Issues in Educational Research30(3): 965–987.
44.
HoffmanECReyesHChuFF, et al. (1991) Cloning of a factor required for activity of the Ah (dioxin) receptor. Science252(5008): 954–958.
45.
JacobBALefgrenL (2011) The impact of research grant funding on scientific productivity. Journal of Public Economics95(9-10): 1168–1177.
46.
KocibaRJKeyesDGBeyerJE, et al. (1978) Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicology and Applied Pharmacology46(2): 279–303.
47.
KogevinasM (2001) Human health effects of dioxins: cancer, reproductive and endocrine system effects. Human Reproduction Update7(3): 331–339.
KulkarniAVAzizBShamsI, et al. (2009) Comparisons of citations in Web of Science, Scopus, and Google Scholar for articles published in general medical journals. JAMA, the Journal of the American Medical Association302(10): 1092–1096.
50.
LeeGChoiADMichosED (2021) Social media as a means to disseminate and advocate cardiovascular research: why, how, and best practices. Current Cardiology Reviews17(2): 122–128.
51.
LongRQYangRT (2001) Carbon nanotubes as superior sorbent for dioxin removal. Journal of the American Chemical Society123(9): 2058–2059.
52.
LongstrethJDHushonJM (1983) Risk assessment for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). In: TuckerREYoungALGrayAP (eds) Human and Environmental Risks of Chlorinated Dioxins and Related Compounds. Boston, MA: Springer, 639–664.
53.
MarinkovicNPasalicDFerencakG, et al. (2010) Dioxins and human toxicity. Arhiv za Higijenu Rada i Toksikologiju61(4): 445–453.
54.
MarquesMDomingoJL (2019) Concentrations of PCDD/fs in human blood: a review of data from the current decade. International Journal of Environmental Research and Public Health16(19).
55.
MarshallNBKerkvlietNI (2010) Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells. Annals of the New York Academy of Sciences1183: 25–37.
56.
Martín-MartínAOrduna-MaleaEThelwallM, et al. (2018) Google Scholar, Web of Science, and Scopus: a systematic comparison of citations in 252 subject categories. Journal of Informetrics12(4): 1160–1177.
57.
MatsudaS (2019) Health policy in Japan - current situation and future challenges. JMA journal2(1): 1–10.
58.
McKayG (2002) Dioxin characterisation, formation and minimisation during municipal solid waste (MSW) incineration: review. Chemical Engineering Journal86(3): 343–368.
59.
MohamedKMajidMIALeongYH, et al. (2020) Dioxins in peat and its formation: an overview. Cogent Environmental Science6(1): 1864870.
60.
NadalMDomingoJLGarciaF, et al. (2009) Levels of PCDD/F in adipose tissue on non-occupationally exposed subjects living near a hazardous waste incinerator in Catalonia, Spain. Chemosphere74(11): 1471–1476.
61.
NeemaSChandrashekarL (2021) Research funding-why, when, and how?Indian Dermatology Online Journal12(1): 134–138.
62.
OgawaTDavisLYoshidaT, et al. (2019) Development and use of a cancer research funding database: promoting strategic global cancer research using the international cancer research partnership database. Studies in Health Technology and Informatics264: 1870–1871.
63.
OhniwaRLTakeyasuKHibinoA (2023) The effectiveness of Japanese public funding to generate emerging topics in life science and medicine. PLoS One18(8): e0290077.
64.
OlieKVermeulenPLHutzingerO (1977) Chlorodibenzo-p-dioxins and chlorodibenzofurans are trace components of fly ash and flue gas of some municipal incinerators in The Netherlands. Chemosphere6(8): 455–459.
65.
Peivasteh-RoudsariLBarzegar-BafroueiRSharifiKA, et al. (2023) Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: a comprehensive review. Heliyon9(7): e18140.
66.
PelclovaDUrbanPPreissJ, et al. (2006) Adverse health effects in humans exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Reviews on Environmental Health21(2): 119–138.
67.
PhilipsonL (2005) Medical research activities, funding, and creativity in Europe: comparison with research in the United States. JAMA, the Journal of the American Medical Association294(11): 1394–1398.
68.
PolandAKnutsonJC (1982) 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annual Review of Pharmacology and Toxicology22: 517–554.
69.
PolandAGloverEKendeAS (1976) Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. Journal of Biological Chemistry251(16): 4936–4946.
70.
RathnaRVarjaniSNakkeeranE (2018) Recent developments and prospects of dioxins and furans remediation. Journal of Environmental Management223: 797–806.
71.
RawatSMeenaS (2014) Publish or perish: where are we heading?Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences19(2): 87–89.
72.
SafeS (1990) Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Critical Reviews in Toxicology21(1): 51–88.
73.
SchwarzMAppelKE (2005) Carcinogenic risks of dioxin: mechanistic considerations. Regulatory Toxicology and Pharmacology: Regulatory Toxicology and Pharmacology43(1): 19–34.
74.
ShakhshirMZyoudSH (2023) Global research trends on diet and nutrition in Crohn's disease. World Journal of Gastroenterology29(20): 3203–3215.
75.
SorgOZenneggMSchmidP, et al. (2009) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites. Lancet (London, England)374(9696): 1179–1185.
76.
SweilehWM (2022) Global research activity on mathematical modeling of transmission and control of 23 selected infectious disease outbreak. Globalization and Health18(1): 4.
77.
SweilehWMZyoudSHAl-JabiSW, et al. (2014) Assessing urology and nephrology research activity in Arab countries using ISI web of science bibliometric database. BMC Research Notes7: 258.
78.
SzajnerJCzarny-DziałakMŻeber-DzikowskaI, et al. (2021) Dioxin-like compounds (DLCS) in the environment and their impact on human health. Journal of Elementology26(2): 419–431.
79.
Tavakoly SanySBHashimRSallehA, et al. (2015) Dioxin risk assessment: mechanisms of action and possible toxicity in human health. Environmental Science and Pollution Research International22(24): 19434–19450.
80.
VaishyaRGuptaBMKappiMM, et al. (2024) Research on non-alcoholic fatty liver disease from Indian subcontinent: a bibliometric analysis of publications during 2001-2022. Journal of Clinical and Experimental Hepatology14(1): 101271.
81.
Van den BergMBirnbaumLBosveldAT, et al. (1998) Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environmental Health Perspectives106(12): 775–792.
82.
Van den BergMBirnbaumLSDenisonM, et al. (2006) The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicological Sciences: An Official Journal of the Society of Toxicology93(2): 223–241.
83.
van den BergMKypkeKKotzA, et al. (2017) WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit-risk evaluation of breastfeeding. Archives of Toxicology91(1): 83–96.
84.
van EckNJWaltmanL (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics84(2): 523–538.
85.
Van EckNJWaltmanL (2011) Text mining and visualization using VOS viewer. ArXiv preprint arXiv:1109.2058.
86.
van EckNJWaltmanL (2013) VOSviewer Manual. Leiden: Univeristeit.
87.
VisserMvan EckNJWaltmanL (2021) Large-scale comparison of bibliographic data sources: Scopus, web of science, dimensions, crossref, and Microsoft academic. Quantitative Science Studies2(1): 20–41.
88.
WardCTMatsumuraF (1978) Fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a model aquatic environment. Archives of Environmental Contamination and Toxicology7(3): 349–357.
89.
WhiteSSBirnbaumLS (2009) An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology. Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews27(4): 197–211.
XingYZhangHSuW, et al. (2019) The bibliometric analysis and review of dioxin in waste incineration and steel sintering. Environmental Science and Pollution Research International26(35): 35687–35703.
92.
XuJYeYHuangF, et al. (2016) Association between dioxin and cancer incidence and mortality: a meta-analysis. Scientific Reports6: 38012.
93.
YaoLZhangLTaiY, et al. (2024) Visual analysis of obesity and hypothyroidism: a bibliometric analysis. Medicine (Baltimore)103(1): e36841.
94.
YuanXShiJPengZ, et al. (2024) Global trends in research of melanoma differentiation-associated gene 5: a bibliometric analysis from 2002 to 2022. Clinical Rheumatology43(3): 1111–1126.
95.
ZainSLatifMTBaharudinNH, et al. (2021) Atmospheric PCDDs/PCDFs levels and occurrences in Southeast Asia: a review. The Science of the Total Environment783: 146929.
96.
ZhangZChenWH (2019) Health hazards of dioxin-like compounds. Journal of Environment and Occupational Medicine36(11): 1007–1009.
97.
ZhangQKlineDEBhattacharyaS, et al. (2013) All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology268(1): 17–26.
98.
ZhangLZhengHJiangST, et al. (2024) Worldwide research trends on tumor burden and immunotherapy: a bibliometric analysis. International Journal of Surgery110(3): 1699–1710.
99.
ZhuJLiuW (2020) A tale of two databases: the use of Web of Science and Scopus in academic papers. Scientometrics123(1): 321–335.
100.
ZielinskiMKaminskaJCzerskaM, et al. (2014) Levels and sources of PCDDs, PCDFs and dl-PCBs in the water ecosystems of central Poland - a mini review. International Journal of Occupational Medicine & Environmental Health27(6): 902–918.
101.
ZyoudSHAl-JabiSWSweilehWM, et al. (2014) A bibliometric analysis of toxicology research productivity in Middle Eastern Arab countries during a 10-year period (2003-2012). Health Research Policy and Systems12: 4.
102.
ZyoudSHAl-JabiSWSweilehWM, et al. (2015) Scientific research related to calcium channel blockers poisoning: bibliometric analysis in Scopus, 1968-2012. Human & Experimental Toxicology34(11): 1162–1170.
103.
ZyoudSHWaringWSAl-JabiSW, et al. (2016) The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. SpringerPlus5(1): 1534.
104.
ZyoudSHWaringWSAl-JabiSW, et al. (2017) Global cocaine intoxication research trends during 1975-2015: a bibliometric analysis of Web of Science publications. Substance Abuse Treatment, Prevention, and Policy12(1): 6.
105.
ZyoudSHShakhshirMAbushanabAS, et al. (2023) Gut microbiota and autism spectrum disorders: where do we stand?Gut Pathogens15(1): 50.
