Laboratory rats were exposed to experimental concentrations of carbon monoxide in air at ambient temperature, to elevated temperature at mospheres from 40°C to 60°C, and to selected CO concentrations in 40-60°C whole-body environments. Incapacitating potency was evaluated by measuring time-to-incapacitation as a function of CO concentration and/or temperature. Incapacitation occurred earlier when CO inhalation was combined with elevated temperature than when the same parameters were applied individ ually ; a fractionally additive effect was noted. An empirical equation was derived for predicting time-to-incapacitation from CO concentration and tem perature data.
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