To investigate risk for cardiovascular disease inpatients with GAD, as well as the effects of comorbid major depression (MD).
Method:
Predrug-trial serum cholesterol and triglyceride levels were assessed in 38 patients with pure GAD and compared with those of 21 patients with mixed GAD and comorbid (MD).
Results:
Significantly higher cholesterol and triglyceride levels were found in the GAD group.
Conclusion:
Increased noradrenergic activity may be responsible for elevations in lipid levels in patients with pure GAD.
IllingworthDRConnorWE. Hyperlipidemia and coronary heart disease. In: ConnorWEBristowJD, editors. Coronary heart disease: Prevention, complication, and treatment. Philadelphia: Lippincott JB; 1985. p 21–42.
2.
KannelWBCastelliWPGordonT. Cholesterol in the prediction of atherosclerotic disease: New perspectives based on the Framingham study. Ann Intern Med1979;90:85–91.
3.
WardleJ. Cholesterol and psychological well-living. J Psychosom Res1995;39:549–62.
4.
MattiasonILindgardeFNilssonJATheorellT. Threat of unemployment and cardiovascular risk factors: Longitudinal study of quality of sleep and serum cholesterol concentrations in men threatened with redundancy. BMJ1990;301:461–6.
5.
TrevisanMCelentanoEMeucciC. Short term effect of natural disasters on coronary artery disease risk factors. Arteriosclerosis1986:6:491–4.
6.
MuldoonMFBachenEAManuckSBWaldsteinSRBrickerPLBennettJA. Acute cholesterol responses to mental stress and change in posture. Arch Intern Med1992;152:775–80.
7.
StoneyCMMathewsKAMcDonaldRHJohnsonCA. Sex differences in lipid, lipoprotein, cardiovascular, and neuroendocrine responses to acute stress. Psychophysiology1988;25:645–56.
8.
RozanskiABaireyNCKrantzDSFriedmanJResserKJMorellM, and others. Mental stress and the induction of silent myocardial ischemia in patients with coronary artery disease. N Engl J Med1988;318:1005–12.
9.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed. Revised. Washington (DC): American Psychiatric Association; 1987.
10.
KahnJPDrusinREKleinDF. Idiopathic cardiomyopathy and panic disorder: Clinical association in cardiac transplant candidates. Am J Psychiatry1988;144:1327–30.
11.
CoryellWNoyesRHouseJD. Mortality among outpatients with anxiety disorders. Am J Psychiatry1988;143:508–10.
12.
CoryellWNoyesRClancyJ. Excess mortality in panic disorder: A comparison with primary unipolar depression. Arch Gen Psychiatry1989;39:701–3.
13.
HaywardCTaylorCBRothWTKingRAgrasWS. Plasma lipid levels in patients with panic disorder or agoraphobia. Am J Psychiatry1989;146:917–9.
14.
BajwaWKAsnigGMSandersonWCIrfanAvan PraagHM. High cholesterol levels in patients with panic disorder. Am J Psychiatry1992;149:376–8.
15.
BrownTAO'LearyTABarlowDH. Generalized anxiety disorder. In: BarlowDH, editor. Clinical handbook of psychological disorders. 2nd edition. New York: Guilford Press; 1993. p 139–88.
16.
SpitzerRLWilliamsJBW. Structured Clinical Interview for DSM-III-R, Upjohn version. New York: Biometrics Research Department, New York State Psychiatric Institute; 1988.
17.
CohnJSMcNamaraJRSchaeferEJ. Lipoprotein cholesterol concentrations in the plasma of human subjects as measured in fed and fasted states. Clin Chem1988;34:2456–9.
18.
HamiltonM. The assessment of anxiety by rating. Br J Med Psychol1959;32:50–5.
19.
ReifmanAWindleM. High cholesterol levels in patients with panic disorder. Am J Psychiatry1993; 150:527.
20.
CharneyDSRedmondEE. Neurobiologic mechanisms in human anxiety: Evidence supporting central noradrenergic hyperactivity. Neuropharmacology1983;22:1531–6.
21.
McCannBSMageeSBroylesFCVaughanMAlbersJJKnoppRH. Acute psychological stress and epinephrine infusion in normolipidemic and hyperlipidemic men: Effects on plasma lipid and apoprotein concentrations. Psychosom Med1995;57:165–76.
22.
NeeseRMCameronOGCurtisGC. Adrenergic function in patients with panic anxiety. Arch Gen Psychiatry1984;41:771–6.
23.
DeAlbertoMJDucimetierePMainardFAlperovitchA. Serum lipids and cholesterol. Lancet1993;341:435.
24.
MorganREPalinkasLABarrett-ConnorELWingardDL. Plasma cholesterol and depressive symptoms in older men. Lancet1993;341:75–9.
25.
GolierJAMarzukPMLeonACWeinerCTardiffK. Low serum cholesterol and attempted suicide. Am J Psychiatry1995;152:419–23.
26.
CooperMAygenM. A relaxation technique in the management of hypercholesterolemia. Journal of Human Stress1979;December:24–7.
