To examine whether there is a relation between nightmares and serum lipid levels.
Methods:
Fifteen subjects who met DSM-IV criteria for the diagnosis of nightmare disorder and 15 healthy control subjects participated in the study. We used an enzymatic colorimetric method for cholesterol and triglyceride determination. We measured high-density lipoprotien (HDL) cholesterol using the direct HDL-cholesterol method. Low-density lipoprotein (LDL) was calculated according to the Friedewald formula.
Results:
Patients with nightmare disorder had lower serum triglyceride, lower total cholesterol, and lower LDL levels than healthy control subjects.
Conclusion:
These findings suggest that nightmares are associated with low serum lipid levels.
AgargunMYAlgunESekerogluRKaraHTarakciogluM.Low cholesterol level in patients with panic disorder: The association with major depression. J Affect Disord1998;50:29–32.
3.
AgargunMYKaraHAlgünESekerogluRTarakçiogluM.High cholesterol level in patients with sleep panic. Biol Psychiatr1996;40:1064–5.
4.
AgargunMYSekerogluMRKaraHÖzerÖATombulTKýranÜSelviY.Sleep-related violence and low serum cholesterol: A preliminary study. Psychiatr Clin Neurosci2002;56:195–8.
5.
NielsenTZadraA.Dreaming disorders. In: Principles and practice of sleep medicine. KrygerMHRothTDementW, editors. Philedelphia (PA): WB Saunders Company; 2000. p 753–72.
6.
FirstMBSpitzerRLGibbonMWilliamsJBW. Structured clinical interview for DSM-IV clinical version (SCID-I-CV). Washington (DC): American Psychiatric Press; 1997.
7.
FriedewaldWTLevyRIFredricskonDS. Estimation of the concentration of the low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem1972;18:499–502.
8.
SPSS Inc. Statistical Package for the Social Sciences (SPSS) for windows, Version 9.01. Chicago (IL): SPSS Inc; 1999.
9.
AdrienJ.Neurobiological bases for the relation between sleep and depression. Sleep Med Rev2002; 6:341–51.
10.
PortasCMBjorvatnBUrsinR.Serotonin and the sleep/wake cycle: Special emphasis on microdialysis studies. Prog Neurobiol2000;60:13–35.
11.
Pace-SchottEFGershTSilvestriRStickgoldRSalzmanCHobsonJA. SSRI treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjects. J Sleep Res2001;10:129–42.
12.
LepkifkerEDannonPNIancuIZivRKotlerM.Nightmares related to fluoxetine treatment. Clin Neuropharmacol1995;18:90–4.
13.
De BoerMOp den VeldeWFalgerPJHovensJEDe GroenJHVan DuijnH.Fluvoxamine treatment for chronic PTSD: A pilot study. Psychother Psychosom1992;57:158–63.
14.
EbbenMLequericaASpielmanA.Effects of pyridoxine on dreaming: A preliminary study. Percept Mot Skills2002;94:135–40.
DarnauderyMPallaresMBouyerJJLe MoalMMayoW.Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties. Neuroscience1999;92:583–8.
17.
RupprechtRHauserCATrappTHolsboerF.Neurosteroids: Molecular mechanisms of action and psychopharmacological significance. J Steroid Biochem Mol Biol1996;5:163–8.
18.
EngelSRGrantKA. Neurosteroids and behavior. Int Rev Neurobiol2001;46:321–48.
