Trapianto di rene da donatore vivente in modalità crociata quale nuova strategia per espandere il trapianto di rene da donatore vivente in coppie di difficile trapiantabilità immunologica

Abstract

Novel strategy in living donor kidney transplantation to outcome biological barriers

Living donor kidney transplantation (LKD) is considered the best type of transplant for end-stage renal disease patients in terms of organ quality and survival. However, ABO incompatibility and positive cross-match remain the most frequent immunological barriers. The novel strategy of kidney paired donation (KPD) has been proposed to facilitate transplantation in patients who have a healthy and willing donor but present this type of barriers.

The first experiences of KPD in a single centre were carried out by creating large regional or national registries that increase the choice in difficult-to-match patients. Our experience shows that referring to the National Italian Registry for identifying a correct pair, allows performing KPD with good outcomes of LKD in cases that would otherwise not be feasible.