Functional disturbances of the immune system have been detected more often among persons affected by epilepsy than in the general population. In the February-July period of 2007 a specific questionnaire on the relationship between epilepsy and immunological response was sent to 27 specialized Centres for Epilepsy in nine Italian regions. 15,388 epileptic patients attended twenty-seven Centers during this six-month period. 3.3% (n=502) of these patients suffered an immune disease. This is the first national survey on the relationship between epilepsy and immunological response in current clinical practice.
VezzaniAGranataT. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia2005; 46:1724–43.
2.
KanterICHuttnerHBStaykov. Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus. Epilepsia2008; 49:914–20.
3.
ChoiJSooKyongK. Role of brain inflammation in EpileptogenesisYonsei Med J2008; 49:1–18.
4.
VezzaniAMonetaDRichichiCAliprandiMBurrowsSJRavizzaTPeregoCDe SimoniMG. Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis. Epilepsia2002; 43(S):30–5.
5.
SinhaPPatilSAJayalekshmySSatishchandraP. Do cytokines have any role in epilepsy?Epilepsy Res2008; 82:171–6.
6.
Mlodzikowska-AlbrechtJSteinbornBZarowskiM. Cytokines, epilepsy and antiepileptic drugs - is there a mutual influence?Pharmacol Rep2007; 59:129–38.
7.
BilliauADWittersPCeulemansBKasranAWoutersCLagaeL. Intravenous immunoglobulins in refractory childhood - onset epilepsy: effects on seizure frequency, EEG activity, and cerebrospinal fluid cytokines profile. Epilepsia2007; 48:1739–49.
8.
ErrichielloLPerruoloGPascarellaAFormisanoPMinettiCStrianoSZaraFStrianoP. Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: A study on 233 patients. J Neuroimmunol2009; 211:120–3.
9.
TakahashiYMoriHMishinaM. Autoantibodies and cell-mediated autoimmunity to NMDA-type GluRepsilon2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua. Epilepsia2005; 46(S):152–8.
10.
CimazR. Any increased risk of autoimmune disease?Lupus2004; 13:736–9.
11.
ErikssonKPeltolaJKeranenTHaapalaAMKoivikkoM. High prevalence of antiphospholipid antibodies in children with epilepsy: a controlled study of 50 cases. Epilepsy Res2001; 46:129–37.
12.
VezzaniABaramTZ. New roles for interleukin-1 Beta in the mechanisms of epilepsy. Epilepsy Current2007; 7:45–50.
13.
VezzaniABalossoSRavizzaT. The role of Cytokines in the pathophysiology of epilepsy. Brain, Behav Immun2008; 22:797–803.
14.
VincentAIraniSRLangB. The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins. Curr Opin Neurol. 2010; 23:144–50.
15.
BilliauADWoutersCHLagaeLG. Epilepsy and the immune system: is there a link?Eur J Paediatr Neurol2005; 9:29–42.
