Trichinella Spiralis Infection is Mediated by MCP-1 and MIP-2,While Echinococcus Granulosus is Strongly Mediated by MCP-1,but Not MIP-2

Abstract

The chemokine supergene family are small proteins (8–10 KD) inducible in a number of pathophysiological processes. C-X-C family members are specific largely on neutrophils; whereas C-C chemokines act primarily on monocytes, T-cells, basophils and eosinophils. A wide variety of cell types produce chemokines in response to stimuli, including: infections, mitogens and inflammatory cytokines. Here we found that parasitic diseases, such as Trichinella spiralis and Echinococcus granulosus produce, MCP-1 (β-chemokine) and MIP-2 (α-chemokine), or MCP-1, respectively. The specificity of production of these chemokines in two parasitic diseases may help to achieve therapeutic strategies in inhibiting inflammation.

Keywords

Trichinella spiralis Echinococcus granulosus Inflammation chemokines MCP-1 MIP-2

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