Abstract
The chemokine supergene family are small proteins (8–10 KD) inducible in a number of pathophysiological processes. C-X-C family members are specific largely on neutrophils; whereas C-C chemokines act primarily on monocytes, T-cells, basophils and eosinophils. A wide variety of cell types produce chemokines in response to stimuli, including: infections, mitogens and inflammatory cytokines. Here we found that parasitic diseases, such as Trichinella spiralis and Echinococcus granulosus produce, MCP-1 (β-chemokine) and MIP-2 (α-chemokine), or MCP-1, respectively. The specificity of production of these chemokines in two parasitic diseases may help to achieve therapeutic strategies in inhibiting inflammation.
