The Effects of Streptokinase used Intravesically on the Urothelium

Abstract

The aim of this experimental study has been to research the effects of streptokinase instillation on the urothelium. Fifteen mature male New Zealand rabbits were divided into 4 experimental groups and saline (Group 1) or streptokinase (Group 2–4) were instilled (3 ml) into the bladder in different doses for 30 minutes. The rabbits were euthanized at 30 days after intravesical instillation and cystectomy was performed. All bladders were evaluated macroscopically and histologically under light microscopy. It has been established that streptokinase has no harmful effect on the urothelium such as inflammation, fibrosis, mucosal atypia and/or thickness in the bladder wall. As a result, streptokinase instillation into the bladder to resolve clotting is a safe treatment method and seems to be a satisfactory alternative to other methods.