– Forty patients affected by locally advanced carcinoma of the bladder were submitted to up-front chemotherapy followed by TUR and radiotherapy. A complete response was obtained in 27 patients (67.5%). A residual mass was present in 13 (32.5%) patients. At a mean follow-up of 38 months (range: 18–112 months), 7 patients showed a recurrence that was superficial in 3 cases and infiltrating the muscular layer in 4. Fifteen patients (37.5%), 12 of whom disease-free, are alive with a mean survival of 65 months. Five more patients died of non-related disease.
FairW.R.: Organ conservation in deeply invasive bladder cancer. In: SmithP.H., Pavone-MacalusoM. (eds.): Urological Oncology. Reconstructive surgery, organ conservation and restoration of function. Progress in clinical and biological research. EORTC Genitourinary Group Monograph 10. Alan R. Liss, New York, 119–126, 1991.
2.
Pavone-MacalusoM., SerrettaV., CorselliG., JacqminD., SylvesterR., De PauwM., SplinterT.A.W. and members of the Genitourinary Group of the European Organization for Research and Treatment of Cancer. In: VillavicencioH., FairW.R. (eds.): Evaluation of chemotherapy in bladder cancer. (Report of the Société Internationale d'Urologie), Churchill Livingstone, Edinburgh, 161–170, 1992.
3.
SplinterT.A.W., Pavone-MacalusoM., JacqminD., RobertsJ.T., CarpentierP., de PauwM., SylvesterR.: A European Organization for Research and Treatment of Cancer. Genitourinary Group, Phase II study of chemotherapy in stage T3-4 NO-x MO transitional cell cancer of the bladder: evaluation of clinical response. J. Urol., 148: 1793–96, 1992.
