Abstract
— From 1991 to April 1995, 490 patients with urogenital tract neoplasms were diagnosed in the Hospital Mauriziano of Turin. 68 (13.9%) patients showed a multiple primary malignant neoplasm (MPMN), of whom 13 had urothelial and respiratory tract neoplasm 13/68 (10.8%): 7 cases of bladder-laryngo neoplasm, 4 of bladder-lung neoplasm, 2 of bladder-nose neoplasm. Similar aetiological factors were involved in these associations (smoking, analgesic abuse and occupational exposure to industrial toxic substances) but the increase was due to correct histopathological classification, increase in single neoplasms (in particular larynx and bladder neoplasms) and increase in survival rate. Progressive reduction in mortality from cancer of the larynx may favour the increase of bladder-larynx neoplasm association recommending extreme vigilance of the patients. The Authors propose to patients with larynx neoplasm a follow-up with cytological urinary tests aimed at early discovery and treatment of the bladder neoplasm.
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