Clinical and pathological staging and histological grading do not always have sufficient value to predict the behaviour of prostatic carcinoma after prostatectomy. Many studies have suggested that DNA ploidy can provide additional prognostic information. DNA ploidy was determined by flow cytometry on paraffin-embedded tissue from 44 radical prostatectomies for carcinoma. The percentage of aneuploid tumours was higher among poorly differentiated neoplasms, in advanced stage and in cases with progression of disease, also considering the same stage and grade. DNA ploidy can represent a significant prognostic parameter in the post-operative evaluation of patients with prostatic carcinoma.
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