In BPH patients, obstruction leads to a progressive modification in the structure of the bladder wall, with histo-pathological changes which are often irreversible. In order to detect these changes and their possible correlation with function, muscle biopsies of the bladder were taken from 28 patients during endoscopic resection for benign prostatic hyperplasia. The samples were examined by means of electron microscope to show ultrastructural charges. The magnitude of the lesions can be correlated to function, seriousness and duration of the obstruction. Detecting histo-pathological damage can justify earlier treatment in obstructed BPH patients, in order to avoid those bladder lesions, which are the probable cause of clinical disorders which may persist even after therapy of the adenoma.
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