Abstract
It might be difficult to diagnose either bladder's flat lesions, such as CIS, or small papillary lesions using white-light endoscopy.
Neoplastic cells can be differentiate from the normal bladder mucous membrane by using Hexyl-ALA. Hexyl aminolevulinate produces protoporphyrin's overstock inside cancer cells causing a clearly visible red fluorescence when these are hit by a predetermined wavelenght light. The purpose of this study is to evaluate effectiveness of PDD (photodynamic diagnosis) by using Hexyl-ALA to identify and treat bladder's surface cancer.
This study considers 39 patients (33 men and 6 women) from November 2008 to January 2009. On these patients were taken, previous filling of their bladders with hexyl aminolevulinate solution, 106 hystological samples (among these: 38 were first step diagnosis, 15 were a second look and 53 were taken for a relapse suspect). The 72.6% of these samples (77) were positive for cancer, while the 27,4% (29) was normal.
Of those 77 samples, 30 were discovered to be positive exclusively by using PDD and include CIS (66.6%), Ta G1–2 (20%), reactive hyperplasia (3.3%) and incipient papillary neoplasia (10%). (Anatomopathologist described the last two lesions as partial nuclear alterations not fullfilling the criteria of pathology). This research proves that, among other diagnostic methods, photodynamic diagnosis has a higher sensibility, although the specificity is lower.
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