C1 inhibitor (C1-INH) regulates, complement, contact system, coagulation and fibrinolysis. Bleeding complications during cardiopulmonary bypass (CPB) have been described in a deficient patient. We report a 72 year old man affected with acquired C1-INH deficiency who successfully underwent CPB.
GardinaliM., CicardiM., AgostoniA., HuglyT.E.Complement activation in extracorporeal circulation: physiological and pathological implications. Pathol Immunopathol Res1986; 5: 352–57.
2.
WoodmanR.C., HarkerL.A.Bleeding complications associated with cardiopulmonary bypass. Blood1990; 1680–97.
3.
AgostoniA., CicardiM.Hereditary and acquired C1 inhibitor deficiency: biological and clinical characteristics in 235 patients. Medicine1992; 71: 206–15.
4.
BonserR.S., DaveJ.R., FimlsComplement activation during bypass in acquired C1 esterase inhibitor deficiency. Ann Thorac Surg1991; 52: 541–3.
5.
EdmundsL.E., SalzmanE.Hemostatic problems, transfusion therapy, and cardiopulmonary bypass in surgical patients. In: CollmanR.W., HirshJ., MurderV.J., SalzmanE.W., eds. Hemostasis and thrombosis basic principles and clinical practice. Third edition. Philadelphia: JB Lippincott Company1994; 956–88.
6.
VidemV., FosseE., MollnesT.E., GarredP., SvennevigJ.L.Time for new concepts about measurement of complement activation by cardiopulmonary bypass?Ann Thorac Surg1992; 54: 725–31.
