Acquired angioedema (AAE) with C1 inhibitor deficiency is often associated to B cell lymphoproliferative disorders or autoimmune diseases. We report a case of AAE associated with IgM anti-cardiolipin antibodies, with frequent edematous attacks, that disappeared completely after a slight immunosuppression and danazol therapy.
BreitbartSIBieloryL. Acquired angioedema: Autoantibody associations and C1q utility as a diagnostic tool. Allergy Asthma Proc2010; 31(5): 428–34.
4.
NettisEColanardiMCLoriaMPVaccaA. Acquired C1-inhibitor deficiency in a patient with systemic lupus erythematosus: A case report and review of the literature. Eur J Clin Invest2005; 35: 781–84.
5.
Bouillet-ClaveyrolasLPonardDDrouetCMassotC. Clinical and biological distinctions between type I and type II acquired angioedema. Am J Med2003; 115(5):420–21.
6.
BossiFFischettiFRegoliD. Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency. J Allergy Clin Immunol2009; 124:1303–10.
7.
D'IncanMTridonAPonardD. Acquired angioedema with C1 inhibitor deficiency: Is the distinction between type I and type II still relevant?Dermatology1999; 199(3):227–30.
8.
PengoVBiasioloAPegoraroC. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb Haemost2005; 93:1147–52.
9.
Bibi-TrikiTEclacheVFrilayY. Déficit acquis en C1 inhibiteur associé à un syndrome lymphoprolifératif: Quatre observations. Rev Med Intern2004; 25:667–72.
10.
MarkovicSNInwardsDJPhylikyRP. Acquired C1 esterase inhibitor deficiency. Ann Intern Med2000; 133:839.
11.
SahasranamanSHowardDRoyS. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol2008; 64:753–67.
