A Comparison of the Effect of Enalapril and Metoprolol on Renal Function,Potassium Balance,Lipid Profile,Cardiac Function,Exercise Tolerance and Quality of Life in Hypertensive Dialysis Patients
Restricted accessResearch articleFirst published online December, 1995
A Comparison of the Effect of Enalapril and Metoprolol on Renal Function,Potassium Balance,Lipid Profile,Cardiac Function,Exercise Tolerance and Quality of Life in Hypertensive Dialysis Patients
26 patients with hypertension while on hemodialysis or continuous ambulatory peritoneal dialysis for end-stage renal diseases were treated first with enalapril and then changed to metoprolol. Both drugs were shown to be similarly effective in controlling blood pressure. There was no difference between the two drugs in their effects on renal function, potassium balance, lipid profile, cardiac function, exercise tolerance, and quality of life. Mild worsening of anemia was observed during treatment with enalapril. No serious side effects were reported. Use of enalapril is safe in the treatment of hypertension in dialysis patients.
ZucchelliP., ZuccalaA.. Control of blood pressure in patients on haemodialysis. In: CameronS., DavisonA.M., GrunfeldJ.P., KerrD., RitzE., eds. The Oxford textbook of nephrology.Oxford University Press1992; 1458–67.
3.
WautersJ.P., WaeberB., BrunnerH.R., GuignardJ.P., TuriniG.A., GavrasH.. Uncontrollable hypertension in patients on hemodialysis: long-term treatment with Captopril and salt subtraction.Clin Nephrol1981; 16: 86–92.
4.
HanssonL., DahlofB., HimmelmannA., SvenssonA.. Angiotensin-Converting enzyme inhibitors in the treatment of essential hypertension. In: Robertson JIS, Nicholls MG, eds. The renin-angiotensin system.Gower Medical Publishing1993; 91: 1–24.
5.
DahlofB.. Factors involved in the pathogenesis of hypertensive cardiovascular hypertrophy - A review.Drugs1988; 35(suppl): 6–26.
6.
DevereuxR.B., PicketingT.G., CodyR.J., LaraghJ.H.. Relation of renin-angiotensin system activity to left-ventricular hypertrophy and function in experimental and human hypertension.J Clin Hypertens1987; 3: 87103.
7.
PfefferM.A., LamasG.A., VaughanD.E., ParisiA.F., BraunwaldE.. Effect of Captopril on progressive ventricular dilatation after anterior myocardial infarction.N Engl J Med1988; 319: 80–6.
8.
FletcherA.E., DolleryC.T.. Side effects associated with inhibitors of angiotensin-converting enzyme. In: Robertson JIS, Nicholls MG, eds. The renin-angiotensin system.Gower Medical Publishing1993; 99: 1–15.
9.
FletcherA.E., BulpittC.J., HawkinsC.M., HavingaT.K., ten BergeB.S., MayJ.F.. Quality of life on antihypertensive therapy: a randomized double-blind controlled trial of Captopril and atenolol.J Hypertens1990; 8: 463–6.
10.
Di BiancoR.D.. Adverse reactions with angiotensin converting enzyme inhibitors.Mex Toxicol1986; 1: 122–41.
11.
FrohlichE.D., CopperR.A., LewisE.J.. Review of the overall experience of Captopril in hypertension.Arch Intern Med1984; 144: 1441–4.
12.
TextorS.C., BravoE.L., FouadF.M., TaraziR.C.. Hyperkalemia in azotemic patients during angiotensin-converting enzyme inhibition and aldosterone reduction with Captopril.Am J Med1982; 73: 719–25.
13.
PapadimitriouM., ZamboulisC., AlexopoulosE.Alarming hyperkalemia during Captopril administration in patients on regular hemodialysis.Dial Transpl1985; 14(8): 473–5.
14.
SempleP.F.. Bronchial hyperreactivity in patients who cough after receiving angiotensin converting enzyme inhibitors.Br Med J1988; 296: 86–8.
15.
TielemansC., MadhounP., LenaersM., SchandeneL., GoldmanM., VanherweghemJ.L.. Anaphylactoid reactions during hemodialysis on AN69 membranes in patients receiving ACE inhibitors.Kidney Int1990; 38: 982–4.
16.
HirakataH., OnoyamaK., IseriK., KumagaiH., FujimiS., OnaeT.. Worsening of anemia induced by long-term use of Captopril in hemodialysis patients.Am J Nephrol1984; 4: 355–60.
17.
HirakataH., OnoyamaK., HoriK., FujishimaM.. Participation of the renin-angiotensin system in the captopril-induced worsening of anemia in chronic hemodialysis patients.Clin Nephrol1986; 26: 27–32.
18.
KamperA.L., NielsenO.J.. Effect of enalapril on haemoglobin and serum erythropoietin in patients with chronic nephropathy.Scand J Clin Lab Invest1990; 50: 611–8.
