The aim of this study was to determine the influence of mechanical factors on free hemoglobin using an F21 hemopump cannula. These factors (flow, rotary speed, reduction of the cross section area of the silicone tube and foreign material on the screw) were tested in a mock circulation with ox blood. Irrelevant increases in free hemoglobin were induced by foreign bodies either in the inlet or on the screw. The hemopump flow was easily affected and almost suppressed by small amounts of foreign bodies on the screw. Other reasons for elevated concentrations of plasma free hemoglobin may imply a general disorder of the pump, anticoagulation, renal function, red cells or a combination of these factors
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