The clinical use of albumin solutions is a controversial issue, that involves albumin as a volume plasma expander, a supplement of total parenteral nutrition and a substance with pharmacological properties. The aim of this review is to show the present role of albumin in the clinical setting. We reviewed experimental and clinical data collected by the Medline System and the bibliographies of relevant articles. Experimental studies were selected on the basis of their historical value and applicability (hypothetical use, correct use) to the clinical setting. At present, it is possible to assert that: a) exogenous albumin is not an ideal colloid; b) the effects on plasma volume expansion are not entirely predictable, especially in pathologic states accompanied by leaky capillary membranes; c) albumin supplementation shows no benefit on many kinds of tissue edema; d) the supplementation of albumin has no influence on outcome. It is possible to demonstrate the role of albumin as a substance with unique properties that make it useful, but further experimental and clinical data will be necessary and represent new areas for future exploration. Given the protein's cost, the routine use of albumin does not appear to be justified, until new data indicate otherwise.
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