Neutrophil Intracellular pH after Exposure of Neutrophils to a Euhydric,Lactate-Based Peritoneal Dialysis Solution and its Euhydric,Bicarbonate-Based Counterpart
Restricted accessResearch articleFirst published online February, 1995
Neutrophil Intracellular pH after Exposure of Neutrophils to a Euhydric,Lactate-Based Peritoneal Dialysis Solution and its Euhydric,Bicarbonate-Based Counterpart
The effects of euhydric, lactate-based peritoneal dialysis solutions and those of their euhydric, bicarbonate-based counterparts, on neutrophil intracellular pH are comparable. This similarity in effects on intracellular acidity may have bearings on the influences of these solutions on cellular functions in general.
ZhouX.J., YuA.W., ZhouF.Q., RyuJ., IngT.S., VaziriN.D.. Effects of an acidic, lactate-based peritoneal dialysis solution and its euhydric, bicarbonate-based counterpart on neutrophilic intracellular pH.Int J Artif Organs1993; 16: 816–9.
3.
ChaimovitzC., RapoportJ., ConfortiA., DouvdevaniA.. Commercial dialysis fluid causes intracellular acidosis in peritoneal macrophages (Mac) (Abstract).J Am Soc Nephrol1992; 3: 407.
4.
LiberekT., TopleyN., JorresA.. Peritoneal dialysis fluid inhibition of polymorphonuclear leukocyte respiratory burst activation is related to the lowering of intracellular pH.Nephron1993; 65: 260–5.
5.
ZhouX.J., YuA.W., IngT.S., VaziriN.D.. Neutrophilic intracellular pH (pHi) after exposure of neutrophils to euhydric, lactate-containing peritoneal dialysis solution (PDS) and its euhydric, bicarbonate-containing counterparts (Abstract).J Am Soc Nephrol1992; 3: 422.
6.
CurnutteJ.T., BabiorB.M.. Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes.J Clin Invest1974; 53: 1662–72.
7.
IngB.L., GuptaD.K., NawabZ.M., ZhuF.Q., RahmanM.A., DaugirdasJ.T.. Suppression of neutrophil superoxide production by conventional peritoneal dialysis solution.Int J Artif Organs1988; 11: 351–4.
8.
SalehA.M., BatlleD.C.. Kinetic properties of the Na+/H+ antiporter of lymphocytes from the spontaneously hypertensive rat: role of intracellular pH.J Clin Invest1990; 85: 1734–9.
9.
CohenR.D., WoodsH.F.. Clinical and biochemical aspects of lactic acidosis.Oxford: Blackwell Scientific Publications, 1976.
10.
De HemptinneA., MarrannesR., VanheelB.. Influence of organic acids on intracellular pH.Am J Physiol1983; 245(Cell physiol 14): C178–83.
11.
DubinskyW.P., RacherE.. The mechanism of lactate transport in human erythrocytes.J Membr Biol1978; 44: 25–36.
12.
DuweA.K., VasS.I., WeatherheadJ.W.. Effect of the composition of peritoneal dialysis fluid on chemiluminescence, phagocytosis and bactericidal activity in vitro.Infect Immun1981; 33: 130–5.
13.
TopleyN., AlobaidiH.M.M., DaviesM., ColesG.A., WilliamsJ.D., LloydD.. The effect of dialysate on peritoneal phagocyte oxidative metabolism.Kidney Int1988; 34: 404–11.
14.
DobosG.J., AndreM., BohlerJ.. Inhibition of C5a-induced actin polymerization, chemotaxis and phagocytosis of human polymorphonuclear neutrophils incubated in a glucose-based dialysis solution.Adv Perit Dial1993; 9: 307–11.
15.
IngT.S., YuA.W., PodilaP.V.. Failure of neutrophils to recover their ability to produce superoxide after stunning by a conventional, acidic, lactate-based peritoneal dialysis solution.Int J Artif Organs1994; 17: 191–4.
16.
IngT.S., HuieD.A., JohnsonV.. Effects of lactate-based and bicarbonate-based peritoneal dialysis solutions on neutrophil oxygen consumption.Artif Organs1995, (in press).
