The handling of low, middle and high molecular weight markers was examined in seven stable dialysis patients during hemofiltration with different membranes. Four membranes were examined in a randomized, crossover order (polysulfone, polyamide, AN69 polyacrylonitrile, Asahi polyacrylonitrile) by measuring plasma and dialysate concentrations of phosphate, creatinine, vitamin B12, β2-microglobulin, furanic acid, hippuric acid, retinolbinding protein, alpha-1-antitrypsin, and albumin. Sieving coefficients and plasma clearances of β-microglobulin or retinol-binding protein were markedly or slightly lower during hemofiltration with the Asahi polyacrylonitrile membrane than with the other membranes (highest removal with polysulfone/AN69 polyacrylonitrile membranes). No differences of obvious clinical relevance could be seen between the four membranes. A high β2-microglobulin removal rate might be important to prevent dialysis-associated amyloidosis.
BergströmJ., FürstP., ZimmermanL.Uremic middle molecules exist and are biologically active.Clin Nephrol1979; 11: 229–38.
2.
NavarroJ., ContrerasP., TouraineJ.L., FreyriaA.M., LaterR., TraegerJ.Are “middle molecules” responsible for toxic phenomena in chronic renal failure?Nephron1982; 32: 301–7.
3.
GejyoF., YamadaT., OdaniS.A new form of amyloid protein associated with chronic hemodialysis was identified as β2-microglobulin.Biochem Biophys Res Comm1985; 129: 701–6.
4.
GorevicP.D., CaseyT.T., StoneW.J., DiRaimondoC.R., PrelliF.C., FrangioneB.Beta-2-microglobulin is an amyloidogenic protein in man.J Clin Invest1985; 76: 2425–9.
5.
BlumbergA., BürgiW.Behaviour of β2-microglobulin in patients with chronic renal failure undergoing hemodialysis, hemodiafiltration and continuous ambulatory peritoneal dialysis (CAPD).Clin Nephrol1987; 27: 245–9.
6.
FlögeJ., GranollerasC., BingelM.β2-microglobulin kinetics during haemodialysis and haemofiltration.Nephrol Dial Transplant1987; 1: 223–8.
7.
KaiserJ.P., HagemannJ., von HerrathD., SchäferK.Different handling of beta2-microglobulin during hemodialysis and hemofiltration.Nephron1988; 48: 132–5.
TielemansC., DratwaM., BergmannP.Continuous ambulatory peritoneal dialysis vs haemodialysis: A lesser risk of amyloidosis?Nephrol Dial Transplant1988; 3: 291–4.
10.
ZingraffJ., BeyneP., UrenaP.Influence of haemodialysis membranes on β2-microglobulin kinetics: in vivo and in vitro studies.Nephrol Dial Transplant1988; 3: 284–90.
ChanardJ., ToupanceO., LavaudS., JaisserF., GilleryP.Serum β2-microglobulin and extracellular fluid volume during haemodialysis.Nephrol Dial Transplant1989; 4: 549–54.
15.
PickertA., BäuerleA., LiebichH.M.Determination of hippuric acid and furanic acid in serum of dialysis patients and control persons by high-performance liquid chromatography.J Chromatogr1989; 495: 95–104.
16.
RockelA., GilgeU., LiewaldA., HeidlandA.Elimination of low molecular weight proteins during hemofiltration.Int J Artif Organs1982; 6; 307–11.
17.
SchneiderH., StreicherE.Mass transfer characterization of a new polysulfone membrane.Artif Organs1985; 9: 180–3.
18.
SchootsA.C., PeetersJ.A.G., GerlagP.G.G.Effect of hemodialysis on serum concentrations of HPLC-ana-lyzed accumulating solutes in uremia.Nephron1989; 53: 208–17.
19.
WizemannV., VelcovskyH.G., BleylH., BrüningS., SchütterleG.Removal of hormones by hemofiltration and hemodialysis with a highly permeable polysulfone membrane.Contr Nephrol1985; 46: 61–8.
20.
LiebichH.M., RislerT., FischerU., RappK., TetschnerB., EggsteinM.Gas chromatographic determination of hippuric acid and a furan-carboxylic acid in plasma of patients with kidney diseases.J Chromatogr1987; 399: 291–4.
21.
SchootsA.C., DijkstraJ.B., RingoirS.M.G., VanholderR., CramersC.A.Are the classical markers sufficient to describe uremic solute accumulation in dialyzed patients? Hippurates reconsidered.Clin Chem1988; 34: 1022–9.
22.
RockelA., AbdelhamidS., FiegelP., WalbD.Elimination of low molecular weight proteins with high flux membranes.Contr Nephrol1985; 46: 69–74.
23.
RockelA., HertelJ., FiegelP., AbdelhamidS., PanitzN., WalbD.Permeability and secondary membrane formation of a high flux polysulfone hemofilter.Kidney Int1986; 30: 429–32.
24.
FloegeJ., GranollerasC., DeschodtG.High-flux synthetic versus cellulosic membranes for β2-microglobulin removal during hemodialysis, hemodiafiltration and hemofiltration.Nephrol Dial Transplant1989; 4: 653–7.
MarsenT., HonigR., SchadS., BarthC., PollokM., BaldamusC.A.How to interpret intratreatment changes in plasma beta-2-microglobulin concentrations.Contrib Nephrol1989; 74: 147–52.
27.
KlinkeB., RockelA., AbdelhamidS., FiegelP., WalbD.Transmembranous transport and adsorption of beta-2-microglobulin during hemodialysis using polysulfone, polyacrylonitrile, polymethyl-methacrylate and cuprammonium rayon membranes.Int J Artif Organs1989; 12: 697–702.
