Hydrogels: A Carrier of Bioactive Agents

Wichterle O. , Lim D. : Hydrophilic gels for biological use. Nature, 185, 117, 1960.

Hoffman A.S. , Ratner B.D. : Synthetic hydrogels for biomedical applications: a review, ACS Polymer Preprints, 16, 272, 1975.

Zaborsky D.R. : ed., Immobilized Enzymes, CRC Press, Cleveland, 1973.

Chang T.M.E. : ed., Biomedical Applications of immobilized Enzymes and Proteins, Vols. I and II, Plenum Press, New York, 1977.

Chibata I. , Tosa T. : Adv. Appl. Microbiol., 22, 1, 1977.

Brodelius P. , Mocbach K. : Adv. Appl. Microbiol., 28, 1, 1982.

Dobo J. : Application of radiation polymerization for the production of water — insoluble enzyme preparation. Acta. Chim. Acadm. Sci. Hung. 63, 453, 1970.

Maeda H. , Yamauchi A. , Suzuki H. : Preparation of immobilized enzymes by γ-ray irradiation, Biochim. Biophys. Acta 315, 18, 1973.

Maeda H. , Suzuki H. , Yamauchi A. : Preparation of immobilized enzymes by electron-beam irradiation, Biotech. Bioneng. 15, 827, 1973.

Maeda H. , Suzuki H. , Yamauchi A. , Sakimae A. : Preparation of immobilized enzymes from acrylic monomers under γ-ray irradiation, Biotech. Bioneng. 17, 119(1975).

Maeda H. , Suzuki H. : Preparation of immobilized enzymes by radiation, Proc. Biochem. 12, 6,9, 1977.

Kawashima K. , Umeda K. : Immobilization of enzymes by radio-polymerization of acrylamide, Biotech. Bioeng. 16, 609, 1974.

Kawashima K. , Umeda K. : Studies on immobilized enzymes by radiopolymerization. Part IV. Preparation of membranous immobilized invertase and its characteristics, Agric. Biol. Chem. 40, 6, 1151, 1976.

Kawashima K. , Umeda K. : Studies on immobilized enzymes by radiopolymerization. Part III. A method for preparing bead-shaped immobilized enzymes, Agric. Biol. Chem. 40, 6, 1143, 1976.

Kumakura M. , Yoshida M. , Asano M. , Kaetsu I. : Immobilization of enzymes by radiation-induced polymerization of glass-forming monomers: double entrapping of enzymes in the presence of various additives, J. Solid Phase Biochem. 2, 279, 1977.

Kaetsu I. , Kumakura M. , Yoshida M. : Enzyme immobilization by radiation-induced polymerization of 2-hydroxyethyl methacrylate at low temperatures, Biotech. Bioeng. 21, 847, 1979.

Kaetsu I. , Kumakura M. , Yoshida M. : Enzyme immobilization by radiation-induced polymerization of hydrophobic glass-forming monomers at low temperatures, Biotech. Bioeng. 21, 863, 1979.

Kaetsu I. , Kamakura H. , Yoshida M. , Asano M. , Himet M. , Tamura M. , Hayashi K. : Immobilization of enzymes by radiation, Rad. Phys. Chem. 14. 595, 1979.

Kaetsu I. , Kamakura M. , Asano M. , Yamada A. , Sakurai Y. : Immobilization of enzymes for medical uses on plastic surfaces by radiation-induced polymerization at low temperatures, J. Biomed. Matls. Res. 14, 199, 1980.

Yoshida M. , Kumakura M. , Kaetsu I. : Immobilization of enzymes by radiation-induced polymerization of glass-forming monomers. 2. Effects of cooling rate and solvent on porosity and activity of immobilized enzymes, Polymer, 20, 9, 1979.

Yoshida M. , Kumakura M. , Kaetsu I. : Immobilization of enzymes by radiation-induced polymerization of glass-forming monomers. 1. Immobilization of some enzymes by poly (2-hydroxyethyl methacrylate), Polymer 20, 3, 1979.

Yoshida M. , Kumakura M. , Kaetsu I. : Immobilization of cellulose in the swollen microsphere by radiation polymerization, Polymer J. 11, 915, 1979.

Kumakura M. , Yoshida M. , Kaetsu I. : Immobilization of glucose isomerase-containing streptomyces phaerochromogenes cells in fine-particle form, Appl. Environm. Microbiol. 37, 310, 1979.

Kumakura M. , Yoshida M. , Kaetsu I. : Immobilization of streptomyces phaerochromogenes by radiation-induced polymerization of glass-forming monomers, Biotech. Bioen. 21, 679, 1979.

Yoshida M. , Kumakura M. , Kaetsu I. : Controlled release of biofunctional substances by radiation-induced polymerization: 2. Release of potassium chloride from porous poly (diethylene glycol methacrylate), Polymer 19, 1379, 1978.

Yoshida M. , Kumakura M. , Kaetsu I. : Controlled release of biofuntional substances by radiation-induced polymerization: 1. Release of potassium chloride by polymerization of various vinyl monomers. Polymer 19, 1375, 1978.

Yoshida M. , Kumakura M. , Kaetsu I. : Controlled drug dissolution by radiation-induced polymerization in the presence of dimethyl-aminoethyl metacrylate — methyl methacrylate copolymer or methacrylic acidmethyl acrylate copolymer, J. Pharmaceut. Sci. 68, 860, 1979.

Yoshida M. , Kumakura M. , Kaetsu I. : Controlled release of 5-fluorouracil from adsorbents containing matrices polymerized by radiation, Polymer J. 11, 775, 1979.

Yoshida M. , Kumakura M. , Kaetsu I. : Drug entrapment for controlled release in radiation-polymerized beads, J. Pharmaceut. Sei. 68, 628, 1979.

Kaetsu I. , Yoshida M. , Yamada A. : Controlled slow release of chemotherapeutic drugs for cancer from matrices prepared by radiation polymerization at low temperatures, J. Biomed. Matls. Res. 14, 185, 1980.

Kaetsu I. , Yoshida M. , Kumakura M. , Yamada A. , Sakurai Y. : Controlled release of multicomposites, Biomaterials 1, 17, 1980.

Pişkin K. , Area E. , Pişkin E. : Radiopolymerized mixture of acrylic acid, methymethacrylate and polyethylenglycol as enzyme support system, Biomat. Med. Dev. Artif. Organs, (Suppl.), 1983 (in press).

Area E. , Pişkin K. , Pişkin E. : Gel artificial cells as enzymes carrier, Life Support Systems (Suppl.), 1, 262, 1983.

Arca E. : M.Sc. Thesis, Ankara, June, 1983.

Area E. , Pişkin K. , Pişkin E. : A gel enzyme support system: copolymerization of MMA and PEG mixtures by irradiation, Artif. Organs (Suppl.), 1983 (in press).

Area E. , Pişkin K. , Pişkin E. : Immobilization of enzymes into porous polymeric gels, Proc. First National Macromolecules Symposium, pp. 267, Ankara 1983.

Chang T.M.S. : ed., Artificial Kidney, Artificial Liver, and Artificial Cells, Plenum Press, New York, 1978.

Bonomini V. , Chang T.M.S. : eds., Hemoperfusion, S. Karger, Basel, 1982.

Pişkin E. , Chang T.M.S. : eds., Hemoperfusion and Artificial Organs, Artificial Organs society, in Turkey, Ankara, 1982.

Pişkin E. , Chang T.M.S. : eds., The Past, Present and Future of Artificial Organs, Meteksan, Ankara, 1983.

Pişkin E. : Coating Material and Methods for Hemoperfusion, in The Past, Present and Future of Artificial Organs, Pişkin E. , Chang T.M.S. , eds., pp. 152, Meteksan, Ankara, 1983.

Hill J.B. , Palaia F.L. , Horres C.R. : In Artificial Organs, Kenedi R.M. , Courtney J.M. , Gaylor J.D.S. , Gilchrist T. , eds., pp. 123, MacMillan Press, Ltd., London, 1977.

Gurland H.J. , Gastro L.A. , Hillebrand G. , Schmidt B. : Sorbent membranes and their medical applications, in Hemoperfusion: Kidney and Liver Support and Detoxification, part 1, Sideman S. , Chang T.M.S. , eds., pp. 105, Memisphere, Washington, 1980.

özdural A.R. , Mann H. , Byrne T. , Pişkin E. : Alginate Immobilized Charcoal Powder; Sorption and Biocompatibility Studies, Life Support Systems. (Suppl.), pp. 55, 1982.

özdural A.R. , Mann H. , Brunner H. , Pişkin E. : Adsorption studies on a New Immobilized Charcoal Powder for Hemoperfusion, in Hemoperfusion and Artificial Organs, Pişkin E. , Chang T.M.S. , eds., pp. 172, Artif. Organs. Soc., in Turkey, Ankara, 1982.

Pişkin E. , Kiremitçi M. , Area E. , Pişkin K. , Evren V. , Mutlu M. : Immobilization of Powdered Activated Carbon into Hydrogels, Proc. Int. Sym. Hem. Artif. Organs, Tianjin, 1983 (in press).