Neutrophil adherence to nylon fibre packed in plastic syringes was determined in blood from patients with fulminant hepatic failure, both before and during charcoal hemoperfusion carried out with prostacyclin infusion and resin hemoperfusion without prostacyclin.
During charcoal hemoperfusion there was a progressive decrease in neutrophil adherence, reaching the lowest value at 4 h (30.4 ± SE 4.8%). After completion of hemoperfusion the adherence value returned to the preperfusion level (53.0 ± 8.4%). These effects are probably attributable to the PGI2 infusion.
No marked changes in neutrophil adherence were observed during resin hemoperfusion.
LangleyP.G., HughesR.D., WilliamsR.: Platelet adhesiveness to glass beads in liver disease.Acta Hematologica, 67, 124–27, 1982.
2.
WestonM.J., LangleyP.G., RubinM.H., HanidM.A., MellonP., WilliamsR.: Platelet function in fulminant hepatic failure and effect of charcoal hemoperfusion.Gut, 18, 897–902, 1977.
3.
RaspF.L., ClawsonC.C., RepineJ.E.: Platelets increase neutrophil adherence in vitro to nylon fiber.Journal of Laboratory and Clinical Medicine, 97, 812–819, 1981.
4.
MacGregorR.R.: Granulocyte adherance changes induced by hemodialysis, endotoxin, epinephrine and glucocorticoids.Annals of Internal Medicine, 86, 35–39, 1977.
5.
CraddockP.R., FehrJ., DalmassoA.P., BrighamK.L., JacobH.S.: Hemodialysis leukopenia: Pulmonary vascular leukostasis resulting from complement activation by dialyser cellophane membranes.Journal of Clinical Investigation, 59, 879–888, 1977.
6.
CraddockP.R., HammerschmidtD., WhiteJ.O., DalmassoA.P., JacobH.S.: Complement (C5a) induced granulocyte aggregation in vitro.A possible mechanism of complement-mediated leukostasis and leukopenia. Journal of Clinical Investigation, 60, 260–264, 1977.
7.
GimsonA.E.S., CanaleseJ., HughesR.D., LangleyP.G., MellonP.J., WilliamsR.: In: Clinical Pharmacology of Prostacyclin. Ed. LewisP.J., O'GradyJ.. pp. 211–217. Raven Press, New York, 1981.
8.
HughesR.D., TonH.Y., LangleyP.G., DaviesM., HanidM.A., MellonP., SilkD.B.A., WilliamsR.: Albumin coated Amberlite XAD-7 resin for hemoperfusion in acute liver failure.Part II. In vivo evaluation. Artificial Organs3, 23–26, 1979.
9.
StecherV.J., ChineaG.L.: The neutrophil adherence assay as a method for detecting unique anti-inflammatory agents.Agents and Actions, 8, 258–262, 1978.
10.
WykeR.J., RajkovicI.A., EddlestonA.L.W.F., WilliamsR.: Defective opsonisation and complement deficiency in serum from patients with fulminant hepatic failure.Gut, 21, 643–649, 1980.
11.
McGillenJ., PattersonR., PhairJ.P.: Adherance of polymorphonuclear leucocytes to nylon, modulation by prostacyclin (PGI2) corticosteroids and complement activation.Journal of Infectious Diseases, 141, 382–388, 1980.
12.
BoxerL.A., AllenJ.M., SchmidtM., YoderM., BaehnerR.L.: Inhibition of polymorphonuclear leukocyte adherence by prostacyclin.Journal of Laboratory and Clinical Medicine, 95, 672–678, 1980.
13.
GuerreroI.C., SchreiberA.D., MacGregorR.R.: Studies of the plasma factor which induces augmented granulocyte adherence during hemodialysis.Nephron, 27, 79–83, 1981.
14.
WykeR.J., CanaleseJ., GimsonA.E.S., WilliamsR.: Bacteremia in patients with fulminant hepatic failure.Liver, 2, 45–52, 1982.
