A newly designed charcoal haemoperfusion device was evaluated by repeated haemoperfusion of conscious dogs. The procedure was tolerated well and the incidence of side effects was low. Alterations to haematolo-gy were small with platelet drops of only 9% and only minor disturbances to plasma chemistry were seen.
AndersonA.C.: The beagle as an experimental dog.Iowa State University Press, 1970.
2.
BuscariniL., BassiF.: Leucocyte loss in haemodialysis.Acta Haematologica, 48, 278, 1972.
3.
ChangT.M.S.: A 1978 perspective of haemoperfusion, Artificial Organs, 2, 359, 1978a.
4.
ChangT.M.S.: Haemoperfusion in chronic schizophrenia.Inter. J. Artif. Organs, 1, 253, 1978b.
5.
FennimoreJ., WatsonP.A., MunroG.D., KolthammerJ.C.: The design and evaluation of a convenient carbon haemoperfusion system.Proc. Eur. Soc. Artif. Organs, 1, 90, 1975.
6.
GazzardB.G., PortmannB., WestonM.J., LangleyP.G., Murray-LyonI.M., DunlopE.H., FlaxH., MellonP.J., RecordC.O., WardM.B., WilliamsR.S.: Charcoal haemoperfusion in the treatment of fulminant hepatic failure.Lancet, i, 1301, 1974.
7.
GelfandM.C., KnepshieldJ.H., CohanS., RamirezB., ShreinerG.E.: Treatment of hepatic coma with haemoperfusion through hydrogel coated charcoal.Kidney Inter.10, S. 239, 1976.
8.
GelfandM.C.: Charcoal haemoperfusion in the treatment of drug overdose.Dialysis and Transpl., 6, 8, 1977.
9.
GelfandM.C.: Haemoperfusion in drug overdose.J. Amer. Med. Assoc., 240, 2761, 1978.
10.
GimsonA.E.S., LangleyP.G., HughesR.D., CanaleseJ., MellonP.J., WilliamsR.S., WoodsH.F., WestonM.J.: Prostacyclin to prevent platelet activation during charcoal haemoperfusion in fulminant hepatic failure.Lancet, i, 173, 1980.
11.
GracaJ.C., GarstE.L.: Early changes in dogs following intravenous pentobarbitone anaesthesia.Anaes-thesiology, 18, 461, 1957.
12.
HampelG., WiddopB.: Experience with haemoperfusion in the treatment of acute drug intoxication.Proc. Eur. Soc. Artif. Organs.5, 202, 1978.
13.
KaplowL.S., GoffinetJ.A.: Profound neutropenia during the early phase of haemodialysis.J. Amer. Med. Assoc., 203, 1135, 1968.
14.
KolthammerJ.C., WatsonP.A., LangS.M., FennimoreJ.: The safety assessment in the dog of a charcoal haemoperfusion column.Clin. Sci. Mol. Med., 51, 515, 1976.
15.
LangS.M., EglenR.M., HenryA.C.: Acetyl-promazine administration: its effects on canine haematology.Vet. Record, 105, 397, 1979.
16.
LangS.M., FennimoreJ.: The development of a haemoperfusion device for chronic use.Proc. International Symposium on Artificial Liver Support. Celle. June 1980. To be published.
17.
LeberH.W., NeuhäuserM., GoubeaudG.: Chronic uraemia — haemodialysis or haemoperfusion? In: Artificial Organs. Eds. KennediR.M.MacMillan Press. Basingstoke. p. 220, 1977.
18.
MacConnellH.L.: The effects of barbiturate on regional blood flows.Canad. Anaesth. Soc. J., 16, 1, 1969.
19.
MacDougallD.F., PownallR., CrightonC.W.: A single catheter technique for haemodialysis in the dog.Vet. Record, 100, 720, 1976.
20.
MandelbaumK., MorganC.R.: The effect of extracorporeal circulation upon insulin.J. Thorac. Car-diovasc. Surg., 55, 526, 1968.
21.
MeddR.K.: An animal model for adsorbent evaluation. In: Artificial Organs. Eds KennediR.M.MacMillan Press, Basingstoke, p. 213, 1977.
22.
OlmsteadF., PageI.H.: Haemodynamic changes in dogs caused by sodium pentobarbitone anaesthesia.Amer. J. Physiol.210, 817, 1966.
23.
PierceW.S., KazamaS., MetzH., ProphetG.A., WaldhausenJ.A.: Twenty four hours left ventricular bypass in the unanaesthetised dog: a study employing transthoracic cannulation and a paracorporeal roller pump.Ann. Surg., 179, 39, 1974.
24.
PrianoL.L., TraberD.L., WilsonR.D.: Barbiturate anaesthesia: an abnormal physiologic situation.J. Pharm. and Exp. Therap., 165, 126, 1969.
25.
RyanC.G., CourtneyJ.M., WoodC.B., HoodR.G., BlumgartL.H.: Activated charcoal haemoperfusion via an extracorporeal circuit in the unrestrained and unanaesthetised rat.Brit. J. Exp. Path., 60, 400, 1979.
26.
UsenikE.A., CronkiteE.P.: Effects of barbiturate anaesthesia on leucocytes in normal and splenec-tomised dogs.Anaesth. Analg., 44, 167, 1965.
27.
VogelS.B., DoughertyS.B., EisenbergM.M., SimmonsR.L., SutherlandD.E.R., HowardR.J., NajarianJ.S., KjellstrandC.M., BuselmeirT.J.: Efficient long-term blood access in the dog.Dial. and Transpl., 7, 743, 1978.
28.
VolansG.N., ValeJ.A., CromeP., WiddopB., GouldingR.: The role of charcoal haemoperfusion in the management of acute poisoning by drugs. In: Artificial Organs. Eds KennediR.M.MacMillan Press, Basingstoke, p. 178, 1977.
29.
WiddopB., MeddR.K., BraithwaiteR.A., ReesA.J., GouldingR.: Experimental drug intoxication: Treatment with charcoal haemoperfusion.Arch. Toxicol.34, 27, 1975.
30.
WilliamsR.S., GimsonA.E.S., HughesR.D., CanaleseJ., LangleyP.G.: The use of charcoal haemoperfusion with PGI2 in the treatment of fulminant hepatic failure.Proc. International Symposium on Artificial Liver Support. Celle, 1980. To be published.
31.
WinchesterJ.F., ApiligaM.T., KennedyA.C.: Short term evaluation of charcoal haemoperfusion combined with dialysis in uraemic patients.Kidney Int., 10, S. 315, 1976.
32.
YatzidesH.: A convenient haemoperfusion microap-paratus over charcoal for the treatment of endogenous and exogenous toxins.1. Its use as an effective artificial kidney. Proc. Eur. Dial. Transpl. Assoc., 1, 83, 1964.
