The blood compatibility of a new polyhema-coated charcoal (Biotec) has been studied in an in-vitro haemoperfusion circuit. The mean inlet platelet levels after 4 hours of perfusion were 99.5 ± SE 4.2% of the initial value and mean white cell levels were 81.9 ± SE 5.8% of initial. No rises in Swank screen filtration pressure were detected. Initial evaluation of this charcoal in patients with fulminant hepatic failure should be possible without platelet-protective agents.
GazzardB.G., WestonM.J., Murray-LyonI.M., FlaxH., RecordC.O., PortmannB., LangleyP.G., DunlopE.H., MellonP.J., WardM.B., WilliamsR.: Charcoal haemoperfusion in the treatment of fulminant hepatic failure.Lancet, i, 1301–1307, 1974.
2.
WestonM.J., LangleyP.G., RubinM.H., HanidA., MellonP.J., WilliamsR.: Platelet function in fulminant hepatic failure and effect of charcoal haemoperfusion.Gut, 18, 897–902, 1977.
3.
LangleyP.G., HughesR.D., DaviesM., WilliamsR.: Platelet retention and effect of heparin on platelet function in acute and chronic liver disease.Clin. Sci.29P, 1979.
4.
LangleyP.G., HughesR.D., TonH.Y., SilkD.B.A., WilliamsR.: The effect of prostaglandin E1 and adenosine on adverse platelet reactions during charcoal haemoperfusion.Thrombosis Research, 13, 351–360, 1978.
5.
LangleyP.G., HughesR.D., TonH.Y., SilkD.B.A., WilliamsR.: The use of prostacyclin (PGI2) in the prevention of platelet aggregation during charcoal haemoperfusion.Int. J. Artif. Org.2, 207–210, 1979.
6.
HughesR.D., TonH.Y., LangleyP.G., SilkD.B.A., WilliamsR.: The use of an in vitro haemoperfusion circuit to evaluate the blood compatibility of albumin-coated Amberlite XAD-7 resin.Int. J. Artif. Org.1, 129–134, 1978.
7.
SwankR.: Screen filtration pressure method in platelet research.Significance and interpretation. Ser. Haematol.1, 146–167, 1968.
8.
HughesR.D.: Unpublished results.
9.
LudlamC.A., MooreS., BoltonA.E., PepperD.S., CashJ.D.: The release of a human platelet-specific protein measured by radioimmunoassay.Thrombosis Research, 6, 543–548, 1975.
10.
GimsonA.E.S., LangleyP.G., HughesR.D., CanaleseJ., MellonP.J., WilliamsR., WoodsH.F., WestonM.J.: Use of prostacyclin to prevent platelet aggregation during charcoal haemoperfusion in fulminant hepatic failure.Lancet, i, 173–175, 1980.
