Albumin-collodion coated activated charcoal was found to effectively remove mercaptan in aqueous solution or in «plasma» solution. An initial clearance of 150 ml/min at a flow rate of 200 ml/min could be obtained. The roles of middle molecules, loosely protein-bound molecules, phenols, mercaptan and other molecules were discussed.
ChangT.M.S.: Hemoperfusion over microencapsulated adsorbent in a patient with hepatic coma.Lancet,2: 1371, 1972.
2.
ChangT.M.S., MigchelsenH.: The characterization of possible «toxic» metabolites in patients with chronic renal failure and hepatic coma.Trans. Am. Soc. Artif. Intern. Organs,19: 314, 1973.
3.
GazzardB.G., WestonM.J., Murray-LyonI.M., FlaxH., RecordC.O., PortmanB., LangleyP.G., DunlopE.H., MellonP.J., WardM.D., WilliamS.R.: Charcoal hemoperfusion in the treatment of fulminating hepatic failure.Lancet, 1 (7870): 1301, 1974.
4.
ChangT.M.S.: Hemoperfusion alone and in series with ultrafiltration or dialysis for uremia, poisoning, and liver failure.Kidney Int.,10: S305, 1976.
GelfandM.C.: Charcoal hemoperfusion: Georgetown University Hospital experience.Artificial Kidney, Artificial Liver, and Artificial Cells. T.M.S., Chang, ed., Plenum Press, New York, p. 117, 1978.
7.
OdakaM., TabataY., KobayashiH., NomuraY., SomaH., HirasawaH., SatoH.: Clinical experience of bead-shaped charcoal hemoperfusion in chronic renal failure and fulminant hepatic failure.Artificial Kidney, Artificial Liver, and Artificial Cells. T.M.S., Chang, ed., Plenum Press, New York, p. 79, 1978.
8.
AmanoI., KanoH., TakahiraH., YamamotoY., ItohK., IwatsukiS., MaedaK., OhtaK.: Hepatic assist system using bead-type charcoal.Artificial Kidney, Artificial Liver, and Artificial Cells. T.M.S., Chang, ed., Plenum Press, New York, p. 89, 1978.
9.
ChangT.M.S., MigchelsenM., CoffeyJ.F., StarkA.: Serum middle molecule levels in uremia during long term intermittent hemoperfusions with the ACAC microcapsule artificial kidney.Trans. Am. Soc. Artif. Intern. Organs,20: 364, 1974.
10.
KaziukaE.N., ChangT.M.S.: In-vitro assessment of the removal of phenols by ACAC hemoperfusion.Int. J. Artif. Organs,2: 215, 1979.
ChangT.M.S.: Removal of endogenous and exogenous toxins by a microencapsulated absorbent.Canadian J. Physiol. Pharm.,47: 1043, 1969.
13.
EllmanG.L.: Tissue sulfhydryl groups.Archives of Biochem. & Biophys.,82: 70, 1959.
14.
ChangT.M.S., Espinosa-MeléndezE., FrancoeurE., EadeN.: ACAC coated charcoal hemoperfusion in the treatment of severe theophylline intoxication in a 3 year old patient.J. of Pediatrics (in press).
15.
GelfandM.C., WinchesterJ.F., KnepshieldJ.H., CohanS.L., SchreinerG.E.: Biochemical correlates of reversal of hepatic coma with coated charcoal hemoperfusion.Trans. Am. Soc. Artif. Intern. Organs,24: 239, 1978.
16.
OpolonP., HuguetC., NusinoviciV., RapinJ.R.: Effects of middle molecule removal on encephalopathy during acute liver failure.Eur. Soc. Artif. Intern. Organs,2: 228, 1976.
17.
ChangT.M.S., ed. Artificial Kidney, Artificial Liver and Artificial Cells.Plenum Press, New York, 1978.
18.
SidemanS., ChangT.M.S., eds. Hemoperfusion: Kidney and Liver Supports and Detoxification.Hemisphere Publishing Co., Washington, D.C., U.S.A. (for 1980).
19.
ChiritoE., ReiterB., ListerC., ChangT.M.S.: Artificial liver: Effect of ACAC microencapsulated charcoal hemoperfusion on fulminant hepatic failure.Artificial Organs J.,1: 76, 1977.
20.
ChangT.M.S., ListerC., ChiritoE., O'KeefeP., ResurreccionE.: Effects of hemoperfusion rate and time of initiation of ACAC charcoal hemoperfusion on the survival of fulminant hepatic failure rats.Trans. Am. Soc. Artif. Intern. Organs,24: 243, 1978.
21.
ChiritoE., ListerC., ChangT.M.S.: Biochemical, hematological and histological changes in a fulminant hepatic failure rat model for artificial liver assessment.Artif. Organs J.,3: 38, 1979.
22.
SilkD.B.A., WilliamsR.: Treatment of Fulminant hepatic failure by charcoal hemoperfusion.Artificial Kidney, Artificial Liver and Artificial Cells. T.M.S., Chang, ed., Plenum Press, New York, p. 125, 1978.
