Infection in orthopedic implant surgery is a serious complication and a major cause of implant failure. Upon implant insertion, a contest between microbial colonization and tissue integration of the implant surface ensues. This race for the surface determines the probability of tissue integration or infection, and the surface properties of the substrate have an important role to play in determining the outcome. A number of strategies have been developed for the modification of implant surfaces to promote bone cell (osteoblast) functions and inhibit bacterial adhesion and growth. In this article, a review is given of these surface modification strategies, in particular those which can achieve the dual aim of bacterial inhibition and simultaneous enhancement of osteoblast functions. Surfaces of these types can be expected to have excellent potential for orthopedic applications. (Int J Artif Organs 2008; 31: 777–85)
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