A new process, based on the micro-co-extrusion of preceramic precursors, has been studied for manufacturing ceramic microelectrodes to be used in biomedical applications. Commercially available silicon polymers were applied and proper doping resulted in electrically conductive ceramic filaments. Chemical reticulation and high-temperature pyrolysis were applied to convert the polymeric resins into Si-O-C ceramic materials. Circular microelectrodes were manufactured with diameters between 100 μm and 5 mm with a different number of inner conductive lines (from 1 to 80). The flexural strength of the filaments depended on the outer diameter size; doping with carbon black produced filaments with an average conductivity of approximately 0.4 S/cm for a 50% weight carbon black load. The results achieved by in vitro studies confirmed a good biological performance of Si-O-C ceramic structures with both hard and soft tissue cell models.
KandelE.R., SchwartzJ.H., JessellT.M.. Principles of neural science.New York: McGraw Hill, 2000.
2.
LozanoA.M.. Surgery for Parkinson's disease, the five W's: why, who, what, where, and when.Adv Neurol2003; 91: 303–7.
3.
EggermontJ.J.. Functional aspects of synchrony and correlation in the auditory nervous system.Concepts Neurosci1993; 4: 105–29.
4.
WilsonM.A., McNaughtonB.L.. Dynamics of the hippocampal ensemble code for space.Science1993; 261: 1055–8.
5.
NicolelisM.A., BaccalaL.A., LinR.C., ChapinJ.K.. Sensorimotor encoding by synchronous neural ensemble activity at multiple levels of the somatosensory system.Science1995; 268: 1353–8.
6.
DeadwylerS.A., HampsonR.E.. Ensemble activity and behavior: what's the code?Science1995; 270: 1316–9.
7.
GrayJ., MaldonadoP.E., WilsonM., McNaughtonB.. Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multiunit recordings in cat striate cortex.Neurosci Methods1995; 63: 43–54.
8.
MaynardE.M.. Neuronal interactions improve cortical population coding of movement direction.J Neurosci1999; 19: 8083–93.
9.
NordhausenC.T., MaynardE.M., NormannR.A.. Single unit recording capabilities of a 100 microwire array.Brain Res1996; 726: 129–40.
10.
SchmidtE.M.. Electrodes for many single neuron recordings. In: Methods for neural ensemble recordings.New York: CRC Press, 1999.
11.
JellemaT., WeijnenJ.. A slim needle-shaped multiwire microelectrode for intracerebral recording.J Neurosci Methods1991; 40: 203–9.
12.
BrannerA., SteinR.B., NormannR.A.. Selective stimulation of cat sciatic nerve using an array of varying-length microelectrodes.J Neurophysiol2001; 85: 1585–94.
13.
MoxonK.A., LeiserS.C., GerhardtG.A., BarbeeK.A., ChapinJ.K.. Ceramic-based multisite electrode arrays for chronic singleneuron recording.IEEE Trans Biomed Eng2004; 51: 647–56.
14.
StarrP.A.. Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations and outcomes.Neurosurg Focus2004; 17: 20–31.
15.
CioffiM., GiordanoC., GusmeroliR., RaimondiM.T., SpinelliA.S., BaranauskasG.. Integrating live cells with semiconductor devices: a biocompatibility assay.Journal of Applied Biomaterials & Biomechanics2005; 3: 112–6.
16.
BaranauskasG., GusmeroliR., SpinelliA.S., GiordanoC., RaimondiM.T.. Cell-based biosensors: current trends of the development.Journal of Applied Biomaterials & Biomechanics2006; 4: 125–34.
17.
MottaP., JudyJ.W.. Multielectrode microprobes for deep-brain stimulation fabricated with a customizable 3-D electroplating process.IEEE Trans Biomed Eng2005; 52: 923–33.
18.
MaccagnanG., ColomboP.. Method for producing and micromanufactored items in ceramic materials, and micromanufactored items produced with said method. PCT Pat. Appl. N WO 2003/011791. May 13, 2000.
19.
ColomboP., PeriniK., BernadoE., CappellettiT., MaccagnanG.. Ceramic microtubes from preceramic polymers.J Am Ceram Soc2003; 86: 1025–7.
20.
PeraleG.. A novel process for the manufacturing of ceramic microelectrodes for biomedical applications.Int J Appl Ceram Tech2008 (in press).
21.
Del CurtoB.. Decreased bacterial adhesion to surface treated titanium.Int J Artif Organs2005; 28: 718–30.
22.
GiordanoC.. Comparison between a novel biomimetic treatment and commercially exploited surfaces.Journal of Applied Biomaterials & Biomechanics2004; 2: 35–44.
AndersonD.J.. Batch fabricated thin film electrodes for stimulation of the central auditory system.IEEE Trans Biomed Eng1989; 36: 693–704.
27.
BurmeisterJ.J., PomerleauF., PalmerM., DayB.K., HuettlP., GerhardtG.A.. Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS.J Neurosci Methods2002; 119: 163–71.
28.
BurmeisterJ., GerhardG.A.. Self-referencing ceramic-based multisite microelectrodes for the detection and the elimination of interferences from the measurement of L-glutamate and other analytes.Anal Chem2001; 73: 1037–42.
